caa a22 4500 445807210 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5674-5 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5674-5 Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies [Elektronische Daten] [Mario Manto, Josep Dalmau, Adrien Didelot, Véronique Rogemond, Jérôme Honnorat] A severe subacute encephalitis associated with auto-antibodies to the NMDA receptor (NMDA-R) has been reported in humans. These antibodies are directed to NR1/NR2 heteromers of the NMDA receptor. We studied the effects of patients' cerebrospinal fluid (CSF) injected in rFr2 (the prefrontal area) on the afferent facilitation in a conditioning paradigm for corticomotor responses. The afferent facilitation was assessed in forelimbs and hindlimbs of rats, before and after application of trains of high-frequency stimulation (HFS) which are known to modulate the excitability of M1. Before HFS, patients' CSF did not modify afferent facilitation. After HFS, the amplitudes of corticomotor responses before conditioning were significantly larger in forelimbs and hindlimbs. There was an increase of the afferent facilitation in forelimbs. The same effect was observed after injection of purified IgGs from patients' sera. Our results highlight that IgGs of patients with NMDA-R antibodies induce a state of corticomotor hyperexcitability following application of HFS over the prefrontal area. Springer-Verlag, 2010 Antibodies nationallicence NMDA receptor nationallicence Encephalitis nationallicence Afferent facilitation nationallicence Conditioning nationallicence Manto Mario FNRS Neurologie ULB, Laboratoire de Neurologie Expérimentale, 808 Route de Lennik, 1070, Bruxelles, Belgium aut Dalmau Josep Division of Neuro-oncology, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, USA aut Didelot Adrien Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut Rogemond Véronique Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut Honnorat Jérôme Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 27-33 0340-5354 258:1<27 2011 258 415 https://doi.org/10.1007/s00415-010-5674-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5674-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Manto Mario FNRS Neurologie ULB, Laboratoire de Neurologie Expérimentale, 808 Route de Lennik, 1070, Bruxelles, Belgium aut NATIONALLICENCE 700 1- Dalmau Josep Division of Neuro-oncology, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, USA aut NATIONALLICENCE 700 1- Didelot Adrien Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut NATIONALLICENCE 700 1- Rogemond Véronique Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut NATIONALLICENCE 700 1- Honnorat Jérôme Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques”, Neurologie B, 69677, Bron, France aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 27-33 0340-5354 258:1<27 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer