caa a22 4500 445807237 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5704-3 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5704-3 Neurometabolic correlates of depression and disability in episodic cluster headache [Elektronische Daten] [Christian Seifert, Michael Valet, Volker Pfaffenrath, Henning Boecker, Katharina Rüther, Thomas Tölle, Till Sprenger] A close association between pain, depression and disability has been shown. However, the neurometabolic correlates of this association have been barely investigated in disease states. Episodic cluster headache is a severe headache syndrome and represents a suitable disease model for the investigation of episodic pain. The aim of this study was to explore the relationship between depression and disability as well as pain scores and brain metabolism in patients with cluster headache during the disease period with repetitive pain attacks, but outside an acute attack. Thirteen patients with cluster headache underwent 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission (FDG-PET) and completed questionnaires on depression and disability as well as a pain visual analogue rating scale (VAS). A positive correlation between the depression scores and glucose metabolism was observed in the insular cortex. A positive correlation between the pain disability scores and brain metabolism was detected in the amygdala. The same applied to the pain visual analogue rating scores. Our data underline the association between severe episodic pain, depression and disability. In addition to this clinical observation, our results stress the importance of the insula and amygdala in pain processing and suffering. The Author(s), 2010 Cluster headache nationallicence Depression nationallicence Disability nationallicence Pain intensity nationallicence FDG-PET nationallicence SVcorrected : Small volume corrected nationallicence FWE : Family wise error nationallicence Seifert Christian Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut Valet Michael Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut Pfaffenrath Volker Neurologische Gemeinschaftspraxis, Leopoldstrasse 59, München, Germany aut Boecker Henning Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany aut Rüther Katharina Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut Tölle Thomas Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut Sprenger Till Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 123-131 0340-5354 258:1<123 2011 258 415 https://doi.org/10.1007/s00415-010-5704-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5704-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seifert Christian Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut NATIONALLICENCE 700 1- Valet Michael Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut NATIONALLICENCE 700 1- Pfaffenrath Volker Neurologische Gemeinschaftspraxis, Leopoldstrasse 59, München, Germany aut NATIONALLICENCE 700 1- Boecker Henning Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany aut NATIONALLICENCE 700 1- Rüther Katharina Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut NATIONALLICENCE 700 1- Tölle Thomas Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut NATIONALLICENCE 700 1- Sprenger Till Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 123-131 0340-5354 258:1<123 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer