caa a22 4500 44580730X CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5703-4 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5703-4 Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas [Elektronische Daten] [Stella Blasel, Waltraud Pfeilschifter, Viola Jansen, Klaus Mueller, Friedhelm Zanella, Elke Hattingen] Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and MR spectroscopy are thought to differentiate tumefactive autoimmune inflammatory demyelinating lesions from glial brain tumours. The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) gradeII-III gliomas. Five patients with single autoimmune inflammatory demyelinating lesions and nine patients with WHO gradeII and III gliomas were examined by DSC-MRI and by two-dimensional (2D) 1H MR spectroscopic imaging (1H-MRSI). rCBV values and metabolite concentrations were normalised to the respective values of the contralateral hemisphere. Normalised rCBV in the tumefactive lesions (mean 2.89, range 1.98-6.74) was in the some high level as in gliomas (mean 2.77, range 1.43-6.22). 1H-MRSI revealed increased normalised choline concentrations in five of six examinations of autoimmune lesions (mean 1.4, range 1.06-1.8) and in eight of nine gliomas (mean 1.35, range 0.92-1.73). Tumefactive autoimmune inflammatory demyelinating lesions not only have imaging appearance of gliomas but may also imitate marked increase of rCBV and Cho in WHO gradeII-III gliomas. Springer-Verlag, 2010 Image analysis nationallicence MRI nationallicence MRS nationallicence Multiple sclerosis nationallicence Tumours nationallicence Blasel Stella Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut Pfeilschifter Waltraud Department of Neurology, University of Frankfurt, Frankfurt, Germany aut Jansen Viola Department of Anaesthesia, University of Frankfurt, Frankfurt, Germany aut Mueller Klaus Department of Neurology, Edinger Institute, University of Frankfurt, Frankfurt, Germany aut Zanella Friedhelm Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut Hattingen Elke Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 113-122 0340-5354 258:1<113 2011 258 415 https://doi.org/10.1007/s00415-010-5703-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5703-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blasel Stella Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut NATIONALLICENCE 700 1- Pfeilschifter Waltraud Department of Neurology, University of Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Jansen Viola Department of Anaesthesia, University of Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Mueller Klaus Department of Neurology, Edinger Institute, University of Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Zanella Friedhelm Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut NATIONALLICENCE 700 1- Hattingen Elke Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 113-122 0340-5354 258:1<113 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer