caa a22 4500 445807342 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5883-y doi (NATIONALLICENCE)springer-10.1007/s00415-010-5883-y Structural gray and white matter changes in patients with HIV [Elektronische Daten] [Michael Küper, K. Rabe, S. Esser, E. Gizewski, I. Husstedt, M. Maschke, M. Obermann] In this cross-sectional study we used magnetic resonance imaging (MRI)-based voxel based morphometry (VBM) in a sample of HIV positive patients to detect structural gray and white matter changes. Forty-eight HIV positive subjects with (n=28) or without (n=20) cognitive deficits (mean age 48.5±9.6years) and 48 age- and sex-matched HIV negative controls underwent MRI for VBM analyses. Clinical testing in HIV patients included the HIV dementia scale (HDS), Unified Parkinson's Disease Rating Scale (UPDRS) and the grooved pegboard test. Comparing controls with HIV positive patients with cognitive dysfunction (n=28) VBM showed gray matter decrease in the anterior cingulate and temporal cortices along with white matter reduction in the midbrain region. These changes were more prominent with increasing cognitive decline, when assigning HIV patients to three cognitive groups (not impaired, mildly impaired, overtly impaired) based on performance in the HIV dementia scale. Regression analysis including all HIV positive patients with available data revealed that prefrontal gray matter atrophy in HIV was associated with longer disease duration (n=48), while motor dysfunction (n=48) was associated with basal ganglia gray matter atrophy. Lower CD4 cell count (n=47) correlated with decrease of occipital gray matter. Our results provide evidence for atrophy of nigro-striatal and fronto-striatal circuits in HIV. This pattern of atrophy is consistent with motor dysfunction and dysexecutive syndrome found in HIV patients with HIV-associated neurocognitive disorder. Springer-Verlag, 2011 Morphometry nationallicence MRI nationallicence Cognition nationallicence Küper Michael Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut Rabe K. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut Esser S. Department of Dermatology, University of Duisburg-Essen, Essen, Germany aut Gizewski E. Department of Neuroradiology, University Hospital Giessen and Marburg, Giessen, Germany aut Husstedt I. Department of Neurology, University of Muenster, Münster, Germany aut Maschke M. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut Obermann M. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1066-1075 0340-5354 258:6<1066 2011 258 415 https://doi.org/10.1007/s00415-010-5883-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5883-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Küper Michael Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Rabe K. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Esser S. Department of Dermatology, University of Duisburg-Essen, Essen, Germany aut NATIONALLICENCE 700 1- Gizewski E. Department of Neuroradiology, University Hospital Giessen and Marburg, Giessen, Germany aut NATIONALLICENCE 700 1- Husstedt I. Department of Neurology, University of Muenster, Münster, Germany aut NATIONALLICENCE 700 1- Maschke M. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Obermann M. Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1066-1075 0340-5354 258:6<1066 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer