caa a22 4500 445807407 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5872-1 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5872-1 Volume reduction in subcortical regions according to severity of Alzheimer's disease [Elektronische Daten] [Jee Roh, Anqi Qiu, Sang Seo, Hock Soon, Jong Kim, Geon Kim, Min-Jeong Kim, Jong-Min Lee, Duk Na] We investigated whether there exists a hierarchical vulnerability of subcortical structures with respect to the severity of Alzheimer's disease (AD). A total of 236 subjects (179 with AD and 57 with normal cognition) underwent 1.5-T magnetic resonance (MR) imaging. The volumes of the five subcortical structures (amygdala, thalamus, putamen, globus pallidus, and caudate nucleus) and hippocampus were analyzed using a large deformation diffeomorphic metric mapping algorithm. The volume changes were evaluated according to the Clinical Dementia Rating (CDR). Correlation between the volumes of the subcortical structures and scores of the cognitive domain-specific neuropsychological tests were evaluated. Volume loss of the amygdala occurred even in the very mild stage of AD (CDR0.5), as did volume loss in the hippocampus. Similar reductions in volume occurred in the thalamus and putamen, however during the mild (CDR1) and moderate (CDR2) stages of AD, respectively. The globus pallidus and caudate nucleus remained devoid of changes until the moderate stage of AD (p<0.01). Volume loss in those subcortical structures correlated with the neuropsychological test scores (p<0.01). Our results suggest that there is a hierarchical vulnerability in subcortical structures according to the clinical severity of AD and that subcortical volume reductions correlate with cognitive impairment. Springer-Verlag, 2011 Alzheimer's disease nationallicence Subcortical structures nationallicence MRI nationallicence Volume nationallicence Roh Jee Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Qiu Anqi Division of Bioengineering, Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut Seo Sang Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Soon Hock Division of Bioengineering, Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut Kim Jong Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Kim Geon Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Kim Min-Jeong Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Lee Jong-Min Department of Biomedical Engineering, Hanyang University, Seoul, South Korea aut Na Duk Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1013-1020 0340-5354 258:6<1013 2011 258 415 https://doi.org/10.1007/s00415-010-5872-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5872-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roh Jee Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Qiu Anqi Division of Bioengineering, Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Seo Sang Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Soon Hock Division of Bioengineering, Clinical Imaging Research Center, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Kim Jong Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Geon Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Min-Jeong Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jong-Min Department of Biomedical Engineering, Hanyang University, Seoul, South Korea aut NATIONALLICENCE 700 1- Na Duk Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1013-1020 0340-5354 258:6<1013 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer