caa a22 4500 445807504 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5876-x doi (NATIONALLICENCE)springer-10.1007/s00415-010-5876-x Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases [Elektronische Daten] [Sarah Jesse, Johannes Brettschneider, Sigurd Süssmuth, Bernhard Landwehrmeyer, Christine von Arnim, Albert Ludolph, Hayrettin Tumani, Markus Otto] In neurodegenerative diseases, cerebrospinal fluid analysis (CSF) is predominantly performed to exclude inflammatory diseases and to perform a risk assessment in dementive disorders by measurement of tau proteins and amyloid beta peptides. However, large scale data on basic findings of CSF routine parameters are generally lacking. The objective of the study was to define a normal reference spectrum of routine CSF parameters in neurodegenerative diseases. Routine CSF parameters (white cell count, lactate and albumin concentrations, CSF/serum quotients of albumin (Q alb), IgG, IgA, IgM, and oligoclonal IgG bands (OCB)) were retrospectively analyzed in an academic research setting. A total of 765 patients (Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), vascular dementia (VD), frontotemporal lobar degeneration (FTLD), progressive supranuclear palsy (PSP), multisystem atrophy (MSA), motor neuron diseases (MND), spinocerebellar ataxia (SCA), Huntington's disease (HD)) and non-demented control groups including a group of patients with muscular disorders (MD). The main outcome measures included statistical analyses of routine CSF parameters. Mildly elevated Q alb were found in a small percentage of nearly all subgroups and in a higher proportion of patients with PSP, MSA, VD, PDD, and MND. With the exception of 1 MND patient, no intrathecal Ig synthesis was observed. Isolated OCBs in CSF were sometimes found in patients with neurodegenerative diseases without elevated cell counts; lactate levels were always normal. A slightly elevated Q alb was observed in a subgroup of patients with neurodegenerative diseases and does not exclude the diagnosis. Extensive elevation of routine parameters is not characteristic and should encourage a re-evaluation of the clinical diagnosis. The Author(s), 2010 Cerebrospinal fluid nationallicence Neurochemical investigation nationallicence Standard routine parameters nationallicence Neurodegenerative disorders nationallicence CSF flow nationallicence Jesse Sarah Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Brettschneider Johannes Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Süssmuth Sigurd Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Landwehrmeyer Bernhard Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut von Arnim Christine Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Ludolph Albert Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Tumani Hayrettin Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Otto Markus Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1034-1041 0340-5354 258:6<1034 2011 258 415 https://doi.org/10.1007/s00415-010-5876-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5876-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jesse Sarah Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Brettschneider Johannes Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Süssmuth Sigurd Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Landwehrmeyer Bernhard Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- von Arnim Christine Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Ludolph Albert Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Tumani Hayrettin Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 700 1- Otto Markus Department of Neurology, University of Ulm, Steinhövelstr. 1, 89075, Ulm, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1034-1041 0340-5354 258:6<1034 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer