caa a22 4500 445807563 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5893-9 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5893-9 Clinical predictors of death in young and middle-aged patients with ischemic stroke or transient ischemic attack: long-term results of the Vienna Stroke Registry [Elektronische Daten] Clinical predictors of ischemic stroke mortality in patients <60years [Stefan Greisenegger, Sonja Zehetmayer, Julia Ferrari, Wilfried Lang, Johanna Fizek, Eduard Auff, Wolfgang Lalouschek, Wolfgang Serles] Data on long-term survival of younger patients with ischemic stroke (IS) are limited. We assessed mortality rates and clinical predictors of survival in patients with IS or transient ischemic attack (TIA) <60years. Consecutive patients with IS or TIA <60years admitted to nine neurological departments in Vienna between 1998 and 2001 were included into the current study. The endpoint was overall mortality. Univariate Cox regression analyses were performed. Significant variables after Bonferroni adjustment were further considered in a multivariate Cox regression analysis. Kaplan-Meier curves and ROC curves were plotted. After excluding patients who died within the first 30days, 661 patients (65% male, mean age 50.2) were followed for a mean of 8.8years. The cumulative mortality rate was 2.4% after 1year and 7.8% after 5years. Diabetes, heavy drinking, heart failure, and age remained significantly associated with mortality in the multivariate Cox regression analysis. Separate analysis of the patient groups <50 and ≥50years showed none of the included factors to be significantly associated with mortality in the younger patient group. In the patient group, ≥50 of the same risk factors as in the whole group analysis showed a statistically significant influence. The observed mortality rates were lower compared to earlier studies conducted in younger patient groups. Although we found subgroups at higher risk of death in the entire population, in patients <50years of age, predictors of survival remained elusive. Springer-Verlag, 2011 Ischemic stroke nationallicence Mortality nationallicence Young adults nationallicence Outcome nationallicence Greisenegger Stefan Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Zehetmayer Sonja Institute of Medical Statistics, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Ferrari Julia Department of Neurology, Hospital Barmherzige Brueder, Große Mohrengasse 9, 1020, Vienna, Austria aut Lang Wilfried Department of Neurology, Hospital Barmherzige Brueder, Große Mohrengasse 9, 1020, Vienna, Austria aut Fizek Johanna Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Auff Eduard Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Lalouschek Wolfgang Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Serles Wolfgang Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1105-1113 0340-5354 258:6<1105 2011 258 415 https://doi.org/10.1007/s00415-010-5893-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5893-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greisenegger Stefan Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 700 1- Zehetmayer Sonja Institute of Medical Statistics, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 700 1- Ferrari Julia Department of Neurology, Hospital Barmherzige Brueder, Große Mohrengasse 9, 1020, Vienna, Austria aut NATIONALLICENCE 700 1- Lang Wilfried Department of Neurology, Hospital Barmherzige Brueder, Große Mohrengasse 9, 1020, Vienna, Austria aut NATIONALLICENCE 700 1- Fizek Johanna Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 700 1- Auff Eduard Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 700 1- Lalouschek Wolfgang Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 700 1- Serles Wolfgang Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1097, Vienna, Austria aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1105-1113 0340-5354 258:6<1105 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer