caa a22 4500 445807644 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5896-6 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5896-6 123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations [Elektronische Daten] [Francesc Valldeoriola, Carles Gaig, Africa Muxí, Ignacio Navales, Pilar Paredes, Francisco Lomeña, Andres De la Cerda, Mariateresa Buongiorno, Mario Ezquerra, Pilar Santacruz, Maria Martí, Eduardo Tolosa] Reduced uptake of 123I- metaiodobenzylguanidine (MIBG) on cardiac gammagraphy and impaired odor identification are markers of neurodegenerative diseases with Lewy bodies (LB) as a pathological hallmark, such as idiopathic Parkinson's disease (IPD). LRRK2 patients present with a clinical syndrome indistinguishable from IPD, but LB have not been found in some cases. Patients with such mutations could behave differently than patients with IPD with respect to MIBG cardiac uptake and olfaction. We studied 14 LRRK2 patients, 14 IPD patients matched by age, gender, disease duration and severity, and 13 age and gender matched control subjects. Olfaction was analyzed through the University of Pennsylvania Smell Identification Test (UPSIT). MIBG cardiac uptake was evaluated through the H/M ratio. The late H/M was 1.44±0.31 for LRRK2 patients, 1.19±0.15 for PD patients, and 1.67±0.16 for control subjects. LRRK2 patients presented lower but not statistically significant MIBG cardiac uptake than controls (p=0.08) and significant higher uptake than PD patients (p=0.04). UPSIT mean scores were 21.5±7.3 for LRRK2 patients, 18.7±6.2 for IPD patients and 29.7±5.7 for control subjects. UPSIT score was lower in both LRRK2 and PD than in controls. In LRRK2 patients a positive correlation was found between myocardial MIBG uptake and UPSIT scores, (R=0.801, p<0.001). In LRRK2 patients, MIBG cardiac uptake was less impaired than in PD; a positive correlation between MIBG cardiac uptake and UPSIT scores was observed. As MIBG cardiac reduced uptake and impaired odor identification are markers of LB pathology, this findings may represent neuropathological heterogeneity among LRRK2 patients. The Author(s), 2011 Genetics nationallicence Lewy bodies nationallicence Parkinson's disease nationallicence Smell nationallicence SPECT nationallicence Valldeoriola Francesc Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Gaig Carles Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Muxí Africa Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Navales Ignacio Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Paredes Pilar Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Lomeña Francisco Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut De la Cerda Andres Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Buongiorno Mariateresa Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Ezquerra Mario Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Santacruz Pilar Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Martí Maria Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Tolosa Eduardo Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1126-1132 0340-5354 258:6<1126 2011 258 415 https://doi.org/10.1007/s00415-010-5896-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5896-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Valldeoriola Francesc Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Gaig Carles Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Muxí Africa Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Navales Ignacio Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Paredes Pilar Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Lomeña Francisco Nuclear Medicine Service, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- De la Cerda Andres Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Buongiorno Mariateresa Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Ezquerra Mario Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Santacruz Pilar Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Martí Maria Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Tolosa Eduardo Movement Disorders Unit, Institut Clínic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1126-1132 0340-5354 258:6<1126 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer