caa a22 4500 445807717 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5878-8 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5878-8 The association between motor subtypes and alexithymia in de novo Parkinson's disease [Elektronische Daten] [Michele Poletti, Daniela Frosini, Cristina Pagni, Claudio Lucetti, Paolo Dotto, Gloria Tognoni, Roberto Ceravolo, Ubaldo Bonuccelli] This study aimed at investigating the association between motor subtypes and alexithymic features in patients with newly diagnosed untreated (de novo) Parkinson's disease. This objective derived from empirical findings about an association between the postural instability/gait difficulty motor subtype of Parkinson's disease and more marked symptoms of depression, an affective disorder strongly related to alexithymia. A total of 42 patients with de novo Parkinson's disease underwent neuropsychiatric assessment, including the toronto alexithymia scale (TAS-20) and the geriatric depression scale (GDS-15). On the basis of scores reported at the unified Parkinson's disease rating scale III section, patients were classified within postural instability/gait difficulty motor subtype tremor dominant motor subtype and mixed motor subtype. Patients of the postural instability/gait difficulty motor subtype reported significantly higher alexithymic features compared to patients of the other motor subtypes. Considering the strong association between alexithymia and depression, this finding is in line with previous findings reporting that the postural instability/gait difficulty subtype of Parkinson's disease is associated to more marked psychopathological features, especially affective features (depression and apathy). In conclusion this brief report suggests the usefulness of an early neuropsychiatric assessment of affect regulation difficulties in PD patients, especially in those with a prevalence of akinetic/rigid symptoms. Springer-Verlag, 2010 De novo Parkinson's disease nationallicence Motor subtype nationallicence Postural instability/gait difficulty nationallicence Alexithymia nationallicence Depression nationallicence Poletti Michele Neurology Unit, USL of Viareggio, Viareggio, Italy aut Frosini Daniela Department of Neuroscience, University of Pisa, Pisa, Italy aut Pagni Cristina Department of Neuroscience, University of Pisa, Pisa, Italy aut Lucetti Claudio Neurology Unit, USL of Viareggio, Viareggio, Italy aut Dotto Paolo Neurology Unit, USL of Viareggio, Viareggio, Italy aut Tognoni Gloria Department of Neuroscience, University of Pisa, Pisa, Italy aut Ceravolo Roberto Department of Neuroscience, University of Pisa, Pisa, Italy aut Bonuccelli Ubaldo Neurology Unit, USL of Viareggio, Viareggio, Italy aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1042-1045 0340-5354 258:6<1042 2011 258 415 https://doi.org/10.1007/s00415-010-5878-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5878-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poletti Michele Neurology Unit, USL of Viareggio, Viareggio, Italy aut NATIONALLICENCE 700 1- Frosini Daniela Department of Neuroscience, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Pagni Cristina Department of Neuroscience, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Lucetti Claudio Neurology Unit, USL of Viareggio, Viareggio, Italy aut NATIONALLICENCE 700 1- Dotto Paolo Neurology Unit, USL of Viareggio, Viareggio, Italy aut NATIONALLICENCE 700 1- Tognoni Gloria Department of Neuroscience, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Ceravolo Roberto Department of Neuroscience, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Bonuccelli Ubaldo Neurology Unit, USL of Viareggio, Viareggio, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1042-1045 0340-5354 258:6<1042 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer