caa a22 4500 445807725 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5899-3 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5899-3 Central neuropathic pain after cerebral venous thrombosis is not so uncommon: an observational study [Elektronische Daten] [Jean-Marc Bugnicourt, Pierre-Yves Garcia, Sandrine Canaple, Chantal Lamy, Olivier Godefroy] Central neuropathic pain (CNP) after stroke has not been studied in sufficient detail and published studies have only included patients with cerebral artery infarct or hemorrhage. This study evaluates the prevalence and factors associated with CNP after cerebral venous (and sinus) thrombosis (CVT). This observational study included all patients admitted to our stroke unit for CVT between January 2002 and December 2007. Clinical data for each patient were collected prospectively and were combined with retrospective review of neuroradiological imaging. CVT patients were systematically examined at the outpatient clinic at 6months, 12months, and annually thereafter, and information on long-term functional outcome, including the presence of CNP, were obtained by open-ended questions. A standardized CNP assessment was performed during the last outpatient visit and was based on the patient's interview and clinical examination. Pain characteristics were assessed by the DN4-questionnaire. CNP was considered when the patient met the following criteria: painful area within the area of sensory abnormalities and follow-up MRI showing brain parenchymal lesion. Among the 43 patients admitted for CVT, seven (16%) developed CNP during the first year of follow-up. Standardized CNP assessment was performed 24.9±11.6months after CVT: eight patients (19%) suffered from CNP. Initial motor deficit (87 vs. 17%, p<0.001), initial sensory deficit (62 vs. 20%, p=0.03), cerebral infarction (75 vs. 23%, p=0.009), right-sided lesion on initial MRI (62 vs. 17%, p=0.017), thalamic (37 vs. 0%, p=0.005) and basal ganglia involvement (25 vs. 0%, p=0.03) and vein of Galen occlusion (25 vs. 0%) were significantly associated with CNP. Despite several methodological limitations, CNP after CVT seems to be frequent, accounting for one-fifth of all cases of CVT. Some clinical and radiological factors might contribute to the development of CNP. Springer-Verlag, 2011 Headache nationallicence Sinus thrombosis nationallicence Outcome nationallicence Pain nationallicence Central neuropathic pain nationallicence Bugnicourt Jean-Marc Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut Garcia Pierre-Yves Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut Canaple Sandrine Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut Lamy Chantal Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut Godefroy Olivier Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1150-1156 0340-5354 258:6<1150 2011 258 415 https://doi.org/10.1007/s00415-010-5899-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5899-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bugnicourt Jean-Marc Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut NATIONALLICENCE 700 1- Garcia Pierre-Yves Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut NATIONALLICENCE 700 1- Canaple Sandrine Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut NATIONALLICENCE 700 1- Lamy Chantal Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut NATIONALLICENCE 700 1- Godefroy Olivier Service de Neurologie, et Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université d'Amiens, Amiens, France aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1150-1156 0340-5354 258:6<1150 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer