caa a22 4500 445807733 CHVBK 20180317145201.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00415-010-5888-6 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5888-6 Disease- and treatment-related effects on the pituitary-gonadal functional axis: a study in men with epilepsy [Elektronische Daten] [Jürgen Bauer, Helke Dierkes, Wieland Burr, Markus Reuber, Birgit Stoffel-Wagner] The consideration of the patient's gender has become an established practice in the choice of antiepileptic drugs (AEDs) for the treatment of epilepsy. This study was undertaken to confirm that temporal lobe epilepsy and the use of hepatic enzyme-inducing AEDs, have a negative effect on sex hormones in men. We calculated the testosterone (T)/luteinizing hormone (LH) ratio to reflect the effects of epilepsy or its treatment on the most important androgen and its pituitary control hormone. Of 324 men with focal epilepsy identified (untreated or on AED monotherapy), 201 were eligible for inclusion (mean age 37.5years¸ mean duration of epilepsy 14.7years). A total of 105 men served as healthy controls (mean age 33.9years). Patients with temporal lobe epilepsy were more likely to show abnormal T/LH ratios than patients with extratemporal epilepsy (p<0.01). Patients receiving AEDs with marked hepatic enzyme-inducing effects were more likely to have low T/LH ratios than patients taking nonenzyme-inducing AEDs or healthy controls (p<0.01). Focus localization and AED choice affect male sex hormones. Findings raise some concerns about the effect of enzyme-inducing AEDs on sexual endocrine functions. Springer-Verlag, 2010 Epilepsy nationallicence Testosterone nationallicence Luteinizing hormone nationallicence Erectile dysfunction nationallicence Antiepileptic drugs nationallicence Bauer Jürgen Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut Dierkes Helke Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut Burr Wieland Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut Reuber Markus Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, Glossop Road, S10 2JF, Sheffield, UK aut Stoffel-Wagner Birgit Department of Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany aut Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1080-1084 0340-5354 258:6<1080 2011 258 415 https://doi.org/10.1007/s00415-010-5888-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5888-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bauer Jürgen Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut NATIONALLICENCE 700 1- Dierkes Helke Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut NATIONALLICENCE 700 1- Burr Wieland Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany aut NATIONALLICENCE 700 1- Reuber Markus Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, Glossop Road, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Stoffel-Wagner Birgit Department of Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/6(2011-06-01), 1080-1084 0340-5354 258:6<1080 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer