caa a22 4500 445807873 CHVBK 20180317145202.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00415-011-6008-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-6008-y Independent patterns of damage to retinocortical pathways in multiple sclerosis without a previous episode of optic neuritis [Elektronische Daten] [Aldina Reis, Catarina Mateus, M. Macário, José de Abreu, Miguel Castelo-Branco] Asymptomatic visual loss is a feature of multiple sclerosis (MS) but its relative impact on distinct retinocortical pathways is still unclear. The goal of this work was to investigate patterns of subclinical visual impairment in patients with MS with and without clinically associated previous optic neuritis (ON). We have used functional methods that assess parvo-, konio- and magnocellular pathways in order to compare pathophysiological mechanisms of damage in a population of 44 subjects with MS (87 eyes), with and without a previous episode of ON. These methods included chromatic contrast sensitivity across multiple chromatic axes (Cambridge Colour Test-parvo/konio pathways), perimetric achromatic contrast sensitivity for the magno pathway [frequency doubling technique (FDT)] and pattern visual evoked potentials (VEP). These measures were correlated with field sensitivity measures obtained using conventional automated static perimetry (ASP) and were also compared with conventional clinical chromatic/achromatic contrast sensitivity chart-based measures. We have found evidence for uncorrelated damage of all retinocortical pathways only in patients with MS without ON. VEP evidence for axonal damage was found in this group supporting the emerging notion of axonal damage even in sub-clinical stages of ON/MS pathophysiology. Only in this group was significant correlation of functional measures with disease stage observed, suggesting that distinct pathophysiological milestones are present before and after ON has occurred. Springer-Verlag, 2011 Multiple sclerosis nationallicence Optic neuritis nationallicence Visual function nationallicence Retinocortical pathways nationallicence Biomarkers nationallicence Reis Aldina Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut Mateus Catarina Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut Macário M. Coimbra University Hospital, Coimbra, Portugal aut de Abreu José Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut Castelo-Branco Miguel Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut Journal of Neurology Springer-Verlag 258/9(2011-09-01), 1695-1704 0340-5354 258:9<1695 2011 258 415 https://doi.org/10.1007/s00415-011-6008-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6008-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reis Aldina Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut NATIONALLICENCE 700 1- Mateus Catarina Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut NATIONALLICENCE 700 1- Macário M. Coimbra University Hospital, Coimbra, Portugal aut NATIONALLICENCE 700 1- de Abreu José Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut NATIONALLICENCE 700 1- Castelo-Branco Miguel Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image (IBILI), University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/9(2011-09-01), 1695-1704 0340-5354 258:9<1695 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer