caa a22 4500 445808101 CHVBK 20180317145203.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00415-011-5924-1 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5924-1 Transcranial magnetic stimulation primes the effects of exercise therapy in multiple sclerosis [Elektronische Daten] [Francesco Mori, Concetta Ljoka, Elisabetta Magni, Claudia Codecà, Hajime Kusayanagi, Fabrizia Monteleone, Andrea Sancesario, Giorgio Bernardi, Giacomo Koch, Calogero Foti, Diego Centonze] Exercise therapy (ET) can be beneficial in disabled multiple sclerosis (MS) patients. Intermittent transcranial magnetic theta burst stimulation (iTBS) induces long-term excitability changes of the cerebral cortex and may ameliorate spasticity in MS. We investigated whether the combination of iTBS and a program of ET can improve motor disability in MS patients. In a double-blind, sham-controlled trial, 30 participants were randomized to three different interventions: iTBS plus ET, sham stimulation plus ET, and iTBS alone. Before and after 2weeks of treatment, measures of spasticity through the modified Ashworth scale (MAS) and the 88 items Multiple Sclerosis Spasticity Score questionnaire (MSSS-88), fatigue through the Fatigue Severity Scale (FSS), daily living activities (ADL) through the Barthel index and health-related quality of life (HRQoL) through the 54 items Multiple Sclerosis Quality of life inventory (MSQoL-54) were collected. iTBS plus ET reduced MAS, MSSS-88, FSS scores, while in the Barthel index and MSQoL-54, physical composite scores were increased. iTBS alone caused a reduction of the MAS score, while none of the measured scales showed significant changes after sham iTBS plus ET. iTBS associated with ET is a promising tool for motor rehabilitation of MS patients. Springer-Verlag, 2011 LTP nationallicence Plasticity nationallicence Quality of life nationallicence Spasticity nationallicence TMS nationallicence Rehabilitation nationallicence Mori Francesco Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Ljoka Concetta Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Magni Elisabetta Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Codecà Claudia Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Kusayanagi Hajime Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Monteleone Fabrizia Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Sancesario Andrea Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Bernardi Giorgio Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Koch Giacomo Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Foti Calogero Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Centonze Diego Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1281-1287 0340-5354 258:7<1281 2011 258 415 https://doi.org/10.1007/s00415-011-5924-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5924-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mori Francesco Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Ljoka Concetta Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Magni Elisabetta Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Codecà Claudia Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Kusayanagi Hajime Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Monteleone Fabrizia Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Sancesario Andrea Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Bernardi Giorgio Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Koch Giacomo Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Foti Calogero Dipartimento di Sanità Pubblica e Biologia Cellulare, Medicina Fisica e Riabilitativa, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Centonze Diego Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1281-1287 0340-5354 258:7<1281 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer