caa a22 4500 44580811X CHVBK 20180317145203.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00415-011-5927-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-5927-y Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study [Elektronische Daten] [Kazumasa Kume, Haruo Hanyu, Tomohiko Sato, Kentaro Hirao, Soichiro Shimizu, Hidekazu Kanetaka, Hiofumi Sakurai, Toshihiko Iwamoto] We investigated the effects of cardiovascular risk factors, such as hypertension, diabetes mellitus, and hypercholesterolemia, on longitudinal regional cerebral blood flow (rCBF) changes in Alzheimer's disease (AD). We followed 68 outpatients with probable AD for an average of 40months. They were divided into three groups based on no (n=24), single (n=27), and multiple (n=17) vascular risk factors. We assessed longitudinal changes on the Mini-Mental State Examination, Functional Assessment Staging scores, and in rCBF deficits using repeated single photon emission computed tomography (SPECT) using N-isopropyl-p-[123I] iodoamphetamine. During follow-up, the multiple vascular risk factor group showed faster cognitive and functional decline than the no and single vascular risk factor groups. When compared with the initial SPECT, the follow-up SPECT showed a significant rCBF reduction in widespread regions, including the parietotemporal, frontal, and limbic lobes, in the multiple and single vascular risk factor groups, while there was rCBF reduction in small scattered regions of the temporoparietal lobe in the no vascular risk factor group. Multiple vascular risk factors are associated with a greater rate of decline in cognition, function, and rCBF in patients with AD. Our results highlight the contribution of vascular risk factors on the progression of AD. Springer-Verlag, 2011 Alzheimer disease nationallicence Hypertension nationallicence Diabetes nationallicence Hypercholesterolemia nationallicence Cerebral blood flow nationallicence Progression nationallicence Kume Kazumasa Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Hanyu Haruo Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Sato Tomohiko Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Hirao Kentaro Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Shimizu Soichiro Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Kanetaka Hidekazu Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Sakurai Hiofumi Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Iwamoto Toshihiko Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1295-1303 0340-5354 258:7<1295 2011 258 415 https://doi.org/10.1007/s00415-011-5927-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5927-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kume Kazumasa Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Hanyu Haruo Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Sato Tomohiko Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirao Kentaro Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimizu Soichiro Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Kanetaka Hidekazu Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakurai Hiofumi Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwamoto Toshihiko Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1295-1303 0340-5354 258:7<1295 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer