caa a22 4500 445808217 CHVBK 20180317145203.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00415-011-5923-2 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5923-2 Effects of rTMS on Parkinson's disease: a longitudinal fMRI study [Elektronische Daten] [Nadia González-García, Jorge Armony, Julian Soto, David Trejo, Marco Alegría, René Drucker-Colín] Parkinson's disease is a movement disorder whose principal symptoms are tremor, rigidity, bradykinesia and postural instability. Initially, drugs like l-dopa or dopaminergic agonists are able to control these symptoms, but with the progress of the disease these drugs become less effective. Previous studies have reported that repetitive transcranial magnetic stimulation (rTMS) can improve these motor symptoms. The objective of this study was to investigate the neural mechanisms through which 25Hz rTMS may improve motor symptoms in Parkinson's disease. In a double-blind placebo-controlled study, we evaluated the effects of 25Hz. rTMS in 10 Parkinson's disease patients. Fifteen rTMS sessions were performed over the primary cortex on both hemispheres (one after the other) during a 12-week period. The patients were studied using functional magnetic resonance imaging during performance of a simple tapping and a complex tapping task, 1week before the administration of the first rTMS session and just after the last session. rTMS improved bradykinesia, while functional magnetic resonance imaging showed different cortical patterns in prefrontal cortex when patients performed the complex tapping test. Furthermore, the improvement in bradykinesia is associated with caudate nucleus activity increases in simple tapping. Finally, we observed a relative change in functional connectivity between the prefrontal areas and the supplementary motor area after rTMS. These results show a potential beneficial effect of repetitive transcranial magnetic stimulation on bradykinesia in Parkinson's disease which is substantiated by neural changes observed in functional magnetic resonance imaging. Springer-Verlag, 2011 Trancranial magnetic stimulation nationallicence Parkinson's disease nationallicence fMRI nationallicence Caudate nucleus nationallicence Supplementary motor area nationallicence González-García Nadia Depto. de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apdo. Postal 70-600, 04510, Mexico, D.F., Mexico aut Armony Jorge Douglas Institute and Dept. of Psychiatry, McGill University, Montreal, QC, Canada aut Soto Julian Hospital General de México, Mexico, Mexico aut Trejo David Hospital General de México, Mexico, Mexico aut Alegría Marco Centro Neurológico ABC Santa Fe, Mexico, D.F., Mexico aut Drucker-Colín René Depto. de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apdo. Postal 70-600, 04510, Mexico, D.F., Mexico aut Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1268-1280 0340-5354 258:7<1268 2011 258 415 https://doi.org/10.1007/s00415-011-5923-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5923-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- González-García Nadia Depto. de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apdo. Postal 70-600, 04510, Mexico, D.F., Mexico aut NATIONALLICENCE 700 1- Armony Jorge Douglas Institute and Dept. of Psychiatry, McGill University, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Soto Julian Hospital General de México, Mexico, Mexico aut NATIONALLICENCE 700 1- Trejo David Hospital General de México, Mexico, Mexico aut NATIONALLICENCE 700 1- Alegría Marco Centro Neurológico ABC Santa Fe, Mexico, D.F., Mexico aut NATIONALLICENCE 700 1- Drucker-Colín René Depto. de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apdo. Postal 70-600, 04510, Mexico, D.F., Mexico aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1268-1280 0340-5354 258:7<1268 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer