caa a22 4500 445808365 CHVBK 20180317145203.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00415-011-5915-2 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5915-2 Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease [Elektronische Daten] [Tyler Rolheiser, Heather Fulton, Kimberley Good, John Fisk, J. McKelvey, Christophe Scherfler, Naeem Khan, Ronald Leslie, Harold Robertson] Evidence from imaging, clinical studies, and pathology suggests that Parkinson's disease is preceded by a prodromal stage that predates clinical diagnosis by several years but there is no established method for detecting this stage. Olfactory impairment, which is common in Parkinson's disease and often predates clinical diagnosis, may be a useful biomarker for early Parkinson's. Evidence is emerging that diffusion imaging parameters might be altered in olfactory tract and substantia nigra in the early stages of clinical Parkinson's disease, possibly reflecting pathological changes. However, no study has examined olfaction and diffusion imaging in olfactory tract and substantia nigra in the same group of patients. The present study compared newly diagnosed Parkinson's disease patients with a matched control group using both olfactory testing and diffusion tensor imaging of the substantia nigra and anterior olfactory structures. Fourteen patients with stage 1-2 Hoehn & Yahr Parkinson's disease were matched to a control group by age and sex. All subjects then completed the University of Pennsylvania Smell Identification Test, as well as a series of MRI scans designed to examine diffusion characteristics of the olfactory tract and the substantia nigra. Olfactory testing revealed significant impairment in the patient group. Diffusion tensor imaging revealed significant group differences in both the substantia nigra and anterior olfactory region, with fractional anisotropy of the olfactory region clearly distinguishing the Parkinson's subjects from controls. This study suggests that there may be value in combining behavioral (olfaction) and MRI testing to identify early Parkinson's disease. Since loss of olfaction often precedes the motor symptoms in Parkinson's disease, the important question raised is "will the combination of olfactory testing and MRI (DTI) testing identify pre-motor Parkinson's disease?” Springer-Verlag, 2011 Parkinson's disease nationallicence Diffusion tensor imaging nationallicence Olfactory testing nationallicence Substantia nigra nationallicence Rolheiser Tyler Department of Pharmacology, Dalhousie University, Halifax, NS, Canada aut Fulton Heather Department of Psychology, Dalhousie University, Halifax, NS, Canada aut Good Kimberley Department of Psychiatry, Dalhousie University, Halifax, NS, Canada aut Fisk John Department of Psychiatry, Dalhousie University, Halifax, NS, Canada aut McKelvey J. Department of Medicine/Neurology, Dalhousie University, Halifax, NS, Canada aut Scherfler Christophe Department of Neurology, Innsbruck Medical University, Innsbruck, Austria aut Khan Naeem Department of Diagnostic Imaging, Dalhousie University, Halifax, NS, Canada aut Leslie Ronald Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada aut Robertson Harold Department of Pharmacology, Dalhousie University, Halifax, NS, Canada aut Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1254-1260 0340-5354 258:7<1254 2011 258 415 https://doi.org/10.1007/s00415-011-5915-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5915-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rolheiser Tyler Department of Pharmacology, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Fulton Heather Department of Psychology, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Good Kimberley Department of Psychiatry, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Fisk John Department of Psychiatry, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- McKelvey J. Department of Medicine/Neurology, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Scherfler Christophe Department of Neurology, Innsbruck Medical University, Innsbruck, Austria aut NATIONALLICENCE 700 1- Khan Naeem Department of Diagnostic Imaging, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Leslie Ronald Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Robertson Harold Department of Pharmacology, Dalhousie University, Halifax, NS, Canada aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/7(2011-07-01), 1254-1260 0340-5354 258:7<1254 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer