caa a22 4500 445808411 CHVBK 20180317145203.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6098-6 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6098-6 The impact of sleep and mood disorders on quality of life in Parkinson's disease patients [Elektronische Daten] [Eva Havlikova, Jitse van Dijk, Iveta Nagyova, Jaroslav Rosenberger, Berrie Middel, Tatiana Dubayova, Zuzana Gdovinova, Johan Groothoff] Sleep disturbances are common and often severe in patients with Parkinson's disease (PD) and their symptoms can be present at any time of day. The purpose of our study was to examine how excessive daytime sleepiness or poor nocturnal sleep quality and mood disorders influence the quality of life (QoL) in PD patients. Ninety-three PD patients from eastern Slovakia were recruited (49.5% males, mean age 68.0±9.5years, mean disease duration 6.1±5.9years). Sleep disturbances were measured using the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI); QoL with the Parkinson's Disease Quality of Life Questionnaire (PDQ-39); depression and anxiety with the Hospital Anxiety and Depression Scale (HADS) and disease severity with the Unified Parkinson's Disease Rating Scale (UPDRS). χ 2 test, bivariate correlations and multiple linear regressions were performed. PSQI and ESS had significant correlations with worse QoL (p<0.01, p<0.05, respectively). HADS-D (p<0.01), HADS-A (p<0.01), UPDRS (p<0.01) and disease duration (p<0.05) were also significantly related to worse QoL. In the linear regression analysis, however, only PSQI (p<0.01), anxiety (p<0.001) and UPDRS (p<0.001) remained significant. The model with PSQI explained 74% of the variance, and the model with ESS explained 63% of the variance in PDQ-39 when analyses were performed separately. In an overall model, however, only PSQI remained significant, accounting for 82% of the variance in PDQ-39. Nighttime poor sleep and anxiety are important contributors leading to a worse QoL. As these are treatable conditions, they should be recognized by clinicians and managed properly. Springer-Verlag, 2011 Parkinson's disease nationallicence Quality of sleep nationallicence Anxiety nationallicence Depression nationallicence Disease severity nationallicence Quality of life nationallicence Havlikova Eva Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut van Dijk Jitse Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut Nagyova Iveta Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut Rosenberger Jaroslav Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut Middel Berrie Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut Dubayova Tatiana Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut Gdovinova Zuzana Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut Groothoff Johan Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2222-2229 0340-5354 258:12<2222 2011 258 415 https://doi.org/10.1007/s00415-011-6098-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6098-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Havlikova Eva Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut NATIONALLICENCE 700 1- van Dijk Jitse Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut NATIONALLICENCE 700 1- Nagyova Iveta Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut NATIONALLICENCE 700 1- Rosenberger Jaroslav Graduate School Kosice Institute for Society and Health, Medical Faculty, PJ Safarik University Kosice, Kosice, Slovakia aut NATIONALLICENCE 700 1- Middel Berrie Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Dubayova Tatiana Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut NATIONALLICENCE 700 1- Gdovinova Zuzana Department of Neurology, Medical Faculty, PJ Safarik University Kosice, Trieda SNP 1, 040 01, Kosice, Slovakia aut NATIONALLICENCE 700 1- Groothoff Johan Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2222-2229 0340-5354 258:12<2222 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer