caa a22 4500 445808446 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6109-7 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6109-7 Sleep disturbances in untreated Parkinson's disease [Elektronische Daten] [Jitka Bušková, Jiří Klempíř, Veronika Majerová, Jana Picmausová, Karel Šonka, Robert Jech, Jan Roth, Evžen Růžička] Sleep abnormalities are frequently found in Parkinson's disease (PD). However, it is unclear if they are present from the initial stages of PD. We thus aimed to assess sleep disturbances in newly diagnosed PD patients. We investigated 20 untreated PD patients using the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI) and the PD Sleep Scale (PDSS). Video-polysomnography and multiple sleep latency test (MSLT) were performed in 15 patients and 15 healthy controls. The ESS score was abnormally high in one patient, while short MSLT times were found in three other patients. The PSQI was higher (p<0.05) and the PDSS lower (p<0.001) in patients compared with controls. Video-polysomnography demonstrated a higher percentage of rapid eye movement sleep without atonia (RWA) in patients compared with controls (mean 28 vs. 2.9%, p<0.001), whereas only one patient had clinically manifested rapid eye movement sleep behavior disorder (RBD). Interestingly, the occurrence of RWA correlated with the motor score (ρ=0.65, p<0.05). This study demonstrates that sleep disturbances emerge, in a proportion of patients, from the early stages of PD. RWA is a common finding while RBD is rarely present in early untreated PD. Springer-Verlag, 2011 Parkinson's disease nationallicence Untreated patients nationallicence Subjective sleep perception nationallicence Daytime sleepiness nationallicence Rapid eye movement sleep behavior disorder nationallicence Bušková Jitka First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Klempíř Jiří First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Majerová Veronika First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Picmausová Jana First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Šonka Karel First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Jech Robert First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Roth Jan First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Růžička Evžen First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2254-2259 0340-5354 258:12<2254 2011 258 415 https://doi.org/10.1007/s00415-011-6109-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6109-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bušková Jitka First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Klempíř Jiří First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Majerová Veronika First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Picmausová Jana First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Šonka Karel First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Jech Robert First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Roth Jan First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Růžička Evžen First Faculty of Medicine, Department of Neurology, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University in Prague, Kateřinská 30, 128 21, Prague 2, Czech Republic aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2254-2259 0340-5354 258:12<2254 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer