caa a22 4500 445808454 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6097-7 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6097-7 Physical inactivity in Parkinson's disease [Elektronische Daten] [Marlies van Nimwegen, Arlène Speelman, Esther Hofman-van Rossum, Sebastiaan Overeem, Dorly Deeg, George Borm, Marleen van der Horst, Bastiaan Bloem, Marten Munneke] Patients with Parkinson's disease (PD) are likely to become physically inactive, because of their motor, mental, and emotional symptoms. However, specific studies on physical activity in PD are scarce, and results are conflicting. Here, we quantified daily physical activities in a large cohort of PD patients and another large cohort of matched controls. Moreover, we investigated the influence of disease-related factors on daily physical activities in PD patients. Daily physical activity data of PD patients (n=699) were collected in the ParkinsonNet trial and of controls (n=1,959) in the Longitudinal Aging Study Amsterdam (LASA); data were determined using the LAPAQ, a validated physical activity questionnaire. In addition, variables that may affect daily physical activities in PD were recorded, including motor symptoms, depression, disability in daily life, and comorbidity. Patients were physically less active; a reduction of 29% compared to controls (95% CI, 10-44%). Multivariate regression analyses demonstrated that greater disease severity, gait impairment, and greater disability in daily living were associated with less daily physical activity in PD (R 2=24%). In this large study, we show that PD patients are about one-third less active compared to controls. While disease severity, gait, and disability in daily living predicted part of the inactivity, a portion of the variance remained unexplained, suggesting that additional determinants may also affect daily physical activities in PD. Because physical inactivity has many adverse consequences, work is needed to develop safe and enjoyable exercise programs for patients with PD. The Author(s), 2011 Parkinson's disease nationallicence Physical activity nationallicence Exercise nationallicence Sedentary nationallicence Chronic disease nationallicence van Nimwegen Marlies Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut Speelman Arlène Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut Hofman-van Rossum Esther Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut Overeem Sebastiaan Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Deeg Dorly VU University Medical Centre, EMGO Institute, Amsterdam, The Netherlands aut Borm George Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut van der Horst Marleen VU University Medical Centre, EMGO Institute, Amsterdam, The Netherlands aut Bloem Bastiaan Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Munneke Marten Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2214-2221 0340-5354 258:12<2214 2011 258 415 https://doi.org/10.1007/s00415-011-6097-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6097-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Nimwegen Marlies Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Speelman Arlène Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hofman-van Rossum Esther Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Overeem Sebastiaan Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Deeg Dorly VU University Medical Centre, EMGO Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Borm George Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van der Horst Marleen VU University Medical Centre, EMGO Institute, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Bloem Bastiaan Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Munneke Marten Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2214-2221 0340-5354 258:12<2214 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer