caa a22 4500 445808470 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6108-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6108-8 Subclinical nigrostriatal dopaminergic denervation in the cerebellar subtype of multiple system atrophy (MSA-C) [Elektronische Daten] [Esteban Muñoz, Alex Iranzo, Sebastian Rauek, Francisco Lomeña, Judith Gallego, Doménec Ros, Joan Santamaría, Eduardo Tolosa] Nigrostriatal involvement is considered an additional feature in the new consensus criteria for the diagnosis of the cerebellar variant of multiple system atrophy (MSA-C). However, so far, only a few studies, which include a relative small number of patients, give support to this criterion. Our objective was to assess nigrostriatal dopaminergic innervation in patients with MSA-C without parkinsonism by use of dopamine transporter single photon emission computed tomography (DAT SPECT). Thirteen patients that fulfilled criteria for possible or probable MSA-C and presented no parkinsonian signs, and 12 age-matched healthy controls underwent (123I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ([123I]FP-CIT) SPECT. Patients were also evaluated through the Unified Multiple System Atrophy Rating Scale (UMSARS) and brain magnetic resonance imaging (MRI). The mean duration of the cerebellar syndrome was 3.8±1.7years. DAT SPECT showed a significant decrease of striatal [123I]FP-CIT uptake ratios in patients (p<0.001). Radiotracer uptake reduction was 21% in the entire striatum, 19% in putamen, and 24% in caudate nuclei. Striatal binding ratios were within the normal range in 3 patients. We did not find correlation between striatal uptake and disease duration, age of patients, UMSARS-II score, and pontine diameter. [123I]FP-CIT SPECT shows that most but not all MSA-C patients without parkinsonism have subclinical nigrostriatal dopaminergic denervation which is not related to disease duration, cerebellar dysfunction, or pontine atrophy. Springer-Verlag, 2011 Multiple system atrophy nationallicence MSA-C nationallicence Dopamine transporter nationallicence SPECT nationallicence Nigrostriatal dopaminergic denervation nationallicence Muñoz Esteban Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut Iranzo Alex Sleep Disorders Unit, Neurology Service, ICN, Hospital Clínic i Universitari, IDIBAPS, CIBERNED, Barcelona, Catalunya, Spain aut Rauek Sebastian Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut Lomeña Francisco Nuclear Medicine Service, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain aut Gallego Judith Biophysics Unit, Department of Physiological Sciences I, Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), University of Barcelona, Barcelona, Catalunya, Spain aut Ros Doménec Biophysics Unit, Department of Physiological Sciences I, Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), University of Barcelona, Barcelona, Catalunya, Spain aut Santamaría Joan Sleep Disorders Unit, Neurology Service, ICN, Hospital Clínic i Universitari, IDIBAPS, CIBERNED, Barcelona, Catalunya, Spain aut Tolosa Eduardo Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2248-2253 0340-5354 258:12<2248 2011 258 415 https://doi.org/10.1007/s00415-011-6108-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6108-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muñoz Esteban Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Iranzo Alex Sleep Disorders Unit, Neurology Service, ICN, Hospital Clínic i Universitari, IDIBAPS, CIBERNED, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Rauek Sebastian Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Lomeña Francisco Nuclear Medicine Service, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Gallego Judith Biophysics Unit, Department of Physiological Sciences I, Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), University of Barcelona, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Ros Doménec Biophysics Unit, Department of Physiological Sciences I, Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), University of Barcelona, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Santamaría Joan Sleep Disorders Unit, Neurology Service, ICN, Hospital Clínic i Universitari, IDIBAPS, CIBERNED, Barcelona, Catalunya, Spain aut NATIONALLICENCE 700 1- Tolosa Eduardo Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Villarroel 170, 08036, Barcelona, Catalunya, Spain aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2248-2253 0340-5354 258:12<2248 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer