caa a22 4500 445808497 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6091-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6091-0 Fatigue and progression of corpus callosum atrophy in multiple sclerosis [Elektronische Daten] [Özgür Yaldizli, Stephanie Glassl, Dietrich Sturm, Athina Papadopoulou, Achim Gass, Barbara Tettenborn, Norman Putzki] Fatigue is one of the most disabling symptoms in multiple sclerosis (MS) patients. There is no or only weak correlation between conventional magnetic resonance imaging (MRI) parameters and level of fatigue. The aim of this study was to investigate the relationship between progression of corpus callosum (CC) atrophy and fatigue in MS patients. This was a cohort study in 70 patients with relapsing form of MS (RRMS) and serial MRIs over a mean follow-up of 4.8years [67% female, mean age 42±11years, mean disease duration 9.7±7.6years, mean Expanded Disability Status Scale (EDSS) 2.8±1.6]. Fatigue was assessed by the Fatigue Severity Scale (FSS). CC size was measured with the CC index (CCI). In total, 40% of the patients suffered from fatigue (mean FSS score 5.3±1.1) and 60% patients had no fatigue (mean FSS score of 2.1±1). Patients with fatigue had higher EDSS scores (p=0.01) and CC atrophy was more pronounced in patients with fatigue (−21.8 vs. −12.1%, p=0.005). FSS correlated with CCI change over time (r=−0.33; p=0.009) and EDSS (p=0.008; r=0.361). The association between annualized CCI change and FSS was independent from EDSS, disease duration, gender and age in a multivariate linear regression analysis (p<0.001). Progression of CC atrophy may play a role in the evolution of MS-related fatigue. Springer-Verlag, 2011 Corpus callosum index nationallicence Corpus callosum atrophy nationallicence Brain atrophy nationallicence Fatigue nationallicence Multiple sclerosis nationallicence Yaldizli Özgür Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut Glassl Stephanie Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut Sturm Dietrich Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut Papadopoulou Athina Department of Neurology/Neuroradiology, University of Basel, Basel, Switzerland aut Gass Achim Department of Neurology/Neuroradiology, University of Basel, Basel, Switzerland aut Tettenborn Barbara Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut Putzki Norman Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2199-2205 0340-5354 258:12<2199 2011 258 415 https://doi.org/10.1007/s00415-011-6091-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6091-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yaldizli Özgür Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut NATIONALLICENCE 700 1- Glassl Stephanie Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut NATIONALLICENCE 700 1- Sturm Dietrich Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut NATIONALLICENCE 700 1- Papadopoulou Athina Department of Neurology/Neuroradiology, University of Basel, Basel, Switzerland aut NATIONALLICENCE 700 1- Gass Achim Department of Neurology/Neuroradiology, University of Basel, Basel, Switzerland aut NATIONALLICENCE 700 1- Tettenborn Barbara Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut NATIONALLICENCE 700 1- Putzki Norman Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2199-2205 0340-5354 258:12<2199 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer