caa a22 4500 445808519 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6093-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-6093-y Acute transverse myelitis in demyelinating diseases among the Chinese [Elektronische Daten] [R. Li, W. Qiu, Z. Lu, Y. Dai, A. Wu, Y. Long, Y. Wang, J. Bao, X. Hu] The aim of the study was to characterize the demographic, clinical, and prognostic features of Chinese patients with acute transverse myelitis (ATM). The clinical data from ATM patients in a demyelinating disease database were analyzed retrospectively. Sixty-seven ATM patients with a follow-up duration longer than 2years were identified. The frequency of neuromyelitis optica-related ATM (NMO-ATM) was high in our cohort (40.3%). Recurrent ATM (R-ATM), with a female predominance, was common in total idiopathic ATM (69.0%, 20/29). In R-ATM with longitudinally extensive spinal cord lesions (LESCLs), the high seropositivity of NMO-IgG, spinal cord lesions mostly involved the central gray matter and severer long-term disability were similar to NMO-ATM. In RTM without LESCLs, low seropositivity of NMO-IgG, preferentially involvement of the peripheral white matter and relative better neurological recovery were consistent with multiple sclerosis-related ATM (MS-ATM). The transition rates to MS in patients with acute partial transverse myelitis (APTM) and acute complete transverse myelitis (ACTM) were not significant (16.7 vs. 6.3%, P=0.753), while LESCLs (OR=11.4, P=0.028) were significantly correlated with transition to NMO. The presence of LESCLs was the only variable showing a higher risk for reaching Rankin 3 (hazard ratio: 2.5, 95% CI: 1.0-6.1). Chinese patients with ATM had demographic, clinical, and prognostic features different from those in Western populations. Idiopathic R-ATM, common in Chinese, is a heterogeneous entity that shares partial clinical, spinal MRI and prognostic features with MS-ATM and NMO-ATM. The length of spinal cord lesion, rather than APTM/ACTM, may be a prognostic factor associated with clinical outcome and long-term disability in our population. Springer-Verlag, 2011 Acute transverse myelitis nationallicence Neuromyelitis optica nationallicence Multiple sclerosis nationallicence Demyelinating disease nationallicence Li R. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Qiu W. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Lu Z. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Dai Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Wu A. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Long Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Wang Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Bao J. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Hu X. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2206-2213 0340-5354 258:12<2206 2011 258 415 https://doi.org/10.1007/s00415-011-6093-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6093-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li R. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Qiu W. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Lu Z. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Dai Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wu A. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Long Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Y. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Bao J. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Hu X. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2206-2213 0340-5354 258:12<2206 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer