caa a22 4500 445808551 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6085-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-6085-y Neural substrates of good and poor recovery after hemiplegic stroke: a serial pet study [Elektronische Daten] [G. Nelles, W. Jentzen, A. Bockisch, H. Diener] In this study, we used positron emission tomography (PET) at two different time points to study the temporal evolution of reorganization in patients with good and those without motor recovery from hemiplegia after the occurrence of a stroke. Ten hemiplegic patients with a first subcortical stroke and five healthy control subjects were scanned during passive and active movements at an interval of 8weeks. PET1 was performed 22.8±7.8days after the index stroke. At PET2, 8weeks later, patients were dichotomized to either good recovery or no recovery according to the upper extremity motor component of the Fugl-Meyer score. Increases of regional cerebral blood flow (rCBF) and comparison between groups at PET1 and PET2 were assessed using statistical parametric mapping. At PET 1, activation was found bilaterally in the inferior parietal cortex. Eight weeks later, patients with good recovery showed maximum activation in the contralateral primary somatosensory cortex and overactivation of the contralateral inferior parietal cortex. Patients with poor recovery showed bilateral activation with a maximum in the somatosensory cortex. Studies correlating activation patterns with quality of recovery may identify the neuroanatomical substrates that subserve improved motor function. Such studies may also guide the development of more effective rehabilitative interventions after the occurrence of stroke. Springer-Verlag, 2011 Positron emission tomography nationallicence Hemiplegia nationallicence Motor activity nationallicence Motor recovery nationallicence Somatosensory cortex nationallicence Nelles G. Neurologisches Zentrum, St. Elisabeth-Krankenhaus, Werthmannstr. 1c, 50935, Cologne, Germany aut Jentzen W. Klinik für Nuklearmedizin, Universitätsklinikum Essen, Essen, Germany aut Bockisch A. Klinik für Nuklearmedizin, Universitätsklinikum Essen, Essen, Germany aut Diener H. Neurologische Klinik und Poliklinik, Universitätsklinikum, Essen, Germany aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2168-2175 0340-5354 258:12<2168 2011 258 415 https://doi.org/10.1007/s00415-011-6085-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6085-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nelles G. Neurologisches Zentrum, St. Elisabeth-Krankenhaus, Werthmannstr. 1c, 50935, Cologne, Germany aut NATIONALLICENCE 700 1- Jentzen W. Klinik für Nuklearmedizin, Universitätsklinikum Essen, Essen, Germany aut NATIONALLICENCE 700 1- Bockisch A. Klinik für Nuklearmedizin, Universitätsklinikum Essen, Essen, Germany aut NATIONALLICENCE 700 1- Diener H. Neurologische Klinik und Poliklinik, Universitätsklinikum, Essen, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2168-2175 0340-5354 258:12<2168 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer