caa a22 4500 445808608 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6088-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6088-8 Altered patterns of cortical activation in ALS patients during attention and cognitive response inhibition tasks [Elektronische Daten] [L. Goldstein, I. Newsom-Davis, V. Bryant, M. Brammer, P. Leigh, A. Simmons] Since amyotrophic lateral sclerosis (ALS) can be accompanied by executive dysfunction, it is hypothesised that ALS patients will have impaired performance on tests of cognitive inhibition. We predicted that ALS patients would show patterns of abnormal activation in extramotor regions when performing tests requiring the inhibition of prepotent responses (the Stroop effect) and the inhibition of prior negatively primed responses (the negative priming effect) when compared to healthy controls. Functional magnetic resonance imaging was used to measure activation during a sparse sequence block design paradigm investigating the Stroop and negative priming effects in 14 ALS patients and 8 healthy age- and IQ-matched controls. Behavioural measures of performance were collected. Both groups' reaction times (RTs) reflected the Stroop effect during scanning. The ALS and control groups did not differ significantly for any of the behavioural measures but did show significant differences in cerebral activation during both tasks. The ALS group showed increased activation predominantly in the left middle temporal gyrus (BA 20/21), left superior temporal gyrus (BA 22) and left anterior cingulate gyrus (BA 32). Neither group's RT data showed clear evidence of a negative priming effect. However the ALS group showed decreased activation, relative to controls, particularly in the left cingulate gyrus (BA 23/24), left precentral gyrus (BA 4/6) and left medial frontal gyrus (BA 6). Greater cerebral activation in the ALS group accompanying the performance of the Stroop effect and areas of decreased activation during the negative priming comparison suggest altered inhibitory processing in ALS, consistent with other evidence of executive dysfunction in ALS. The current findings require further exploration in a larger study. The Author(s), 2011 Amyotrophic lateral sclerosis nationallicence fMRI nationallicence Cognitive function nationallicence Response inhibition nationallicence Goldstein L. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut Newsom-Davis I. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut Bryant V. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut Brammer M. King's College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK aut Leigh P. King's College London, Department of Clinical Neuroscience, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, London, UK aut Simmons A. King's College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2186-2198 0340-5354 258:12<2186 2011 258 415 https://doi.org/10.1007/s00415-011-6088-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6088-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldstein L. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Newsom-Davis I. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Bryant V. King's College London, Department of Psychology, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, PO77, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Brammer M. King's College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK aut NATIONALLICENCE 700 1- Leigh P. King's College London, Department of Clinical Neuroscience, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, London, UK aut NATIONALLICENCE 700 1- Simmons A. King's College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2186-2198 0340-5354 258:12<2186 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer