caa a22 4500 445808659 CHVBK 20180317145204.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00415-011-6070-5 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6070-5 Secondary infarction in single or in multiple vascular territories: two different entities following subarachnoid hemorrhage? [Elektronische Daten] [N. de Rooij, C. Frijns, B. Velthuis, G. Rinkel] The pathogenesis of secondary infarctions (SI) after aneurysmal subarachnoid hemorrhage (SAH) is poorly understood. To assess whether SI in single (SSI) or multiple (MSI) vascular territories represent different disease entities, we compared clinical profiles of patients with these patterns of SI. CT/MRI-examinations of 448 patients were reviewed for new infarctions within 28days after SAH, and categorized into SSI or MSI. Only patients with adequate follow-up imaging excluding any new infarctions were included for analysis (269 patients). Procedure-related infarctions were excluded. Odds ratios (ORs) with corresponding 95% confidence intervals (CI) were calculated for patients with SSI or MSI versus patients without SI to analyze differences in demographic characteristics, vascular risk factors, disease-related characteristics and treatment modalities. Thirty-six patients had SSI, 53 MSI and 180 no SI. ORs in MSI-patients were >1.5 times higher compared with ORs in SSI-patients for multiple vascular risk factors [MSI:5.4 (2.3-13) versus SSI:1.2 (0.5-2.8)], poor clinical condition on admission [MSI:4.6 (2.4-8.9) versus SSI:2.4 (1.1-5.2)], initial loss of consciousness [MSI:2.6 (1.3-5.3) versus SSI:1.1 (0.5-2.3)] and large amounts of intraventricular blood [MSI:2.9 (1.4-5.8) versus SSI:1.5 (0.7-3.2)]. In multivariate analysis ORs remained higher in MSI for presence of multiple vascular risk factors [MSI:1.9 (1.2-2.9) versus SSI:1.1 (0.8-1.7)] and initial loss of consciousness [MSI:3.0 (1.0-8.9) versus SSI:1.6 (0.6-4.0)]. Our findings suggest that SSI and MSI after SAH are not distinct disease entities. MSI was related to the same characteristics as SSI but to a larger extent, specifically to the presence of multiple vascular risk factors, initial loss of consciousness, larger amounts of intraventricular blood, and poor clinical status on admission. The Author(s), 2011 Delayed cerebral ischemia nationallicence Secondary infarction nationallicence Subarachnoid hemorrhage nationallicence de Rooij N. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut Frijns C. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut Velthuis B. Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands aut Rinkel G. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2133-2139 0340-5354 258:12<2133 2011 258 415 https://doi.org/10.1007/s00415-011-6070-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6070-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Rooij N. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Frijns C. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Velthuis B. Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Rinkel G. Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/12(2011-12-01), 2133-2139 0340-5354 258:12<2133 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer