caa a22 4500 445808799 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5785-z doi (NATIONALLICENCE)springer-10.1007/s00415-010-5785-z Osteopontin predicts long-term functional outcome among ischemic stroke patients [Elektronische Daten] [M. Mendioroz, I. Fernández-Cadenas, A. Rosell, P. Delgado, S. Domingues-Montanari, M. Ribó, A. Penalba, M. Quintana, J. Álvarez-Sabín, J. Montaner] Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not yet been established. Therefore, we aimed to determine human serum OPN level during acute ischemic stroke and its relationship with patient outcome. We measured OPN levels in 178 consecutive patients with a middle cerebral artery (MCA) occlusion who received fibrinolytic therapy and in 40 control subjects. OPN level was determined by an enzyme-linked immunosorbent assay (ELISA). Bad functional outcome was defined by modified Rankin Scale (mRS) score >2 at 3months after stroke onset. A logistic regression analysis was performed to determine factors that could be independently associated with poor prognosis. OPN levels among stroke patients did not differ from the controls' OPN levels (16.65 vs. 17.83ng/mL, p=0.404). Interestingly, OPN level was increased among those patients who showed worse prognosis at 3months (19.96 vs. 15.48ng/mL, p=0.040). In a logistic regression model, an OPN level >27.22ng/mL was found to be an independent factor for a bad outcome (OR 5.01, 95% CI 1.60-15.72, p=0.006) after adjusting for potential confounders. Those patients showing higher OPN levels before tPA administration displayed a worse prognosis compared to those with lower OPN levels. Further research is necessary to elucidate the role of OPN in ischemic stroke pathophysiology and validate OPN as a useful tool to predict long-term stroke outcome. Springer-Verlag, 2010 Stroke nationallicence Ischemic stroke nationallicence Prognosis nationallicence Biomarker nationallicence Osteopontin nationallicence OPN nationallicence Mendioroz M. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Fernández-Cadenas I. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Rosell A. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Delgado P. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Domingues-Montanari S. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Ribó M. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut Penalba A. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Quintana M. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut Álvarez-Sabín J. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut Montaner J. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 486-493 0340-5354 258:3<486 2011 258 415 https://doi.org/10.1007/s00415-010-5785-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5785-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mendioroz M. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Fernández-Cadenas I. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Rosell A. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Delgado P. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Domingues-Montanari S. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Ribó M. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Penalba A. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Quintana M. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Álvarez-Sabín J. Neurovascular Unit, Neurology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Montaner J. Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 486-493 0340-5354 258:3<486 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer