caa a22 4500 445808802 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5768-0 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5768-0 Early atrophy of pallidum and accumbens nucleus in Huntington's disease [Elektronische Daten] [Simon van den Bogaard, Eve Dumas, Tanka Acharya, Hans Johnson, Douglas Langbehn, Rachael Scahill, Sarah Tabrizi, Mark van Buchem, Jeroen van der Grond, Raymund Roos] In Huntington's disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well investigated, or reported with contradicting results. The aim of our study is to provide a more precise view of the specific atrophy of the subcortical grey matter structures in different stages of Huntington's disease, and secondly to investigate how this influences the clinical manifestations. All TRACK-HD subjects underwent standardised T1-weighted 3T MRI scans encompassing 123 manifest HD (stage 1, n=77; stage 2, n=46), 120 premanifest HD (close to onset n=58, far from onset n=62) and 123 controls. Using FMRIB's FIRST and SIENAX tools the accumbens nucleus, amygdala, brainstem, caudate nucleus, hippocampus, pallidum, putamen, thalamus and whole brain volume were extracted. Results showed that volumes of the caudate nucleus and putamen were reduced in premanifest HD far from predicted onset (>10.8 years). Atrophy of accumbens nucleus and pallidum was apparent in premanifest HD in the close to onset group (0-10.8 years). All other structures were affected to some degree in the manifest group, although brainstem, thalamus and amygdala were relatively spared. The accumbens nucleus, putamen, pallidum and hippocampus had a strong significant correlation with functional and motor scores. We conclude that volume changes may be a sensitive and reliable measure for early disease detection and in this way serve as a biomarker for Huntington's disease. Besides the caudate nucleus and putamen, the pallidum and the accumbens nucleus show great potential in this respect. The Author(s), 2010 Huntington's disease nationallicence Volumetric MRI nationallicence Accumbens nucleus nationallicence Pallidum nationallicence Biomarker nationallicence van den Bogaard Simon Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut Dumas Eve Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut Acharya Tanka Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut Johnson Hans Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut Langbehn Douglas Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut Scahill Rachael UCL Institute of Neurology, University College London, Queen Square, London, UK aut Tabrizi Sarah UCL Institute of Neurology, University College London, Queen Square, London, UK aut van Buchem Mark Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut van der Grond Jeroen Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Roos Raymund Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 412-420 0340-5354 258:3<412 2011 258 415 https://doi.org/10.1007/s00415-010-5768-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5768-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van den Bogaard Simon Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Dumas Eve Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Acharya Tanka Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Johnson Hans Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Langbehn Douglas Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Scahill Rachael UCL Institute of Neurology, University College London, Queen Square, London, UK aut NATIONALLICENCE 700 1- Tabrizi Sarah UCL Institute of Neurology, University College London, Queen Square, London, UK aut NATIONALLICENCE 700 1- van Buchem Mark Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van der Grond Jeroen Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Roos Raymund Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 412-420 0340-5354 258:3<412 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer