caa a22 4500 445808853 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5797-8 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5797-8 The emerging role of vitamin D binding protein in multiple sclerosis [Elektronische Daten] [Giulio Disanto, Sreeram Ramagopalan, Andrea Para, Lahiru Handunnetthi] Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). A growing body of evidence supports a role for vitamin D in MS aetiology. Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels. We review here evidence supporting a role of DBP in MS. Several recent studies show that DBP levels in the cerebrospinal fluid correlate with MS course, being lower during relapses and higher in the secondary progressive phase. Further studies are needed to elucidate the potential use of DBP as a biological marker of MS course, but may be of use given the current lack of diagnostic tools for the prediction of MS development and progression. Springer-Verlag, 2010 Multiple sclerosis nationallicence Vitamin D binding protein nationallicence Cerebrospinal fluid nationallicence Disease course nationallicence Disanto Giulio Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut Ramagopalan Sreeram Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut Para Andrea Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut Handunnetthi Lahiru Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 353-358 0340-5354 258:3<353 2011 258 415 https://doi.org/10.1007/s00415-010-5797-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5797-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Disanto Giulio Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut NATIONALLICENCE 700 1- Ramagopalan Sreeram Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut NATIONALLICENCE 700 1- Para Andrea Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut NATIONALLICENCE 700 1- Handunnetthi Lahiru Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 353-358 0340-5354 258:3<353 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer