caa a22 4500 44580890X CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5783-1 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5783-1 Dietary intake of vitamin D during adolescence and risk of multiple sclerosis [Elektronische Daten] [Kassandra Munger, Tanuja Chitnis, A. Frazier, Edward Giovannucci, Donna Spiegelman, Alberto Ascherio] Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥400IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake=0.73, 95% CI: 0.50-1.07, P=0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies. Springer-Verlag, 2010 Multiple sclerosis nationallicence Vitamin D nationallicence Cohort study nationallicence Epidemiology nationallicence Munger Kassandra Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut Chitnis Tanuja Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA aut Frazier A. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 02115, Boston, MA, USA aut Giovannucci Edward Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, 02115, Boston, MA, USA aut Ascherio Alberto Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 479-485 0340-5354 258:3<479 2011 258 415 https://doi.org/10.1007/s00415-010-5783-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5783-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Munger Kassandra Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Chitnis Tanuja Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Frazier A. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Giovannucci Edward Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Ascherio Alberto Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 479-485 0340-5354 258:3<479 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer