caa a22 4500 445808942 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5786-y doi (NATIONALLICENCE)springer-10.1007/s00415-010-5786-y Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease [Elektronische Daten] [Juan Gómez-Esteban, Beatriz Tijero, Johanne Somme, Roberto Ciordia, Koldo Berganzo, Idoia Rouco, Jose Bustos, Maria Valle, Elena Lezcano, Juan Zarranz] The objective of this study is to assess how the non-motor symptoms of Parkinson's disease (PD), such as depression, cognitive deterioration, neuropsychiatric and sleep disorders, affect the quality of life, and to compare them with the motor symptoms in order to determine their real impact. A cross-sectional study was designed including 99 patients (mean age 68.5±9.9years, duration of disease 8.7±6.2years). Demographic data, onset of PD, years on treatment with levodopa (LD), class of dopaminergic drug prescribed, and dosages were obtained. The following scales were used: quality of life (PDQ-39), Unified Parkinson's Disease Rating Scale (UPDRS I-IV), Parkinson Disease Sleep Scale (PDSS) and daytime sleepiness (Epworth), Mini-Mental State Examination, depression (HAM-D), and the neuropsychiatric inventory (NPI-10). The PDQ-39 summary index (PDQ-39 SI) was 24.7±13.2. A linear regression model including all variables showed that four independent variables accounted for 67.2% of the variance in the PDQ-39 SI (F=33,277; p<0.001): NPI, PDSS, UPDRS IV, and UPDRS I. When sub-items of the NPI, PDSS and UPDRS IV scales are analyzed, significant correlations (p<0.001) are found between the PDQ-39 SI and depression, agitation, apathy, anxiety, hallucinations, delusions, incontinence of urine, morning painful posturing, restlessness in bed, morning fatigue, duration of off periods, unpredictable and predictable off periods, early morning dystonia, and sudden off periods. Neuropsychiatric symptoms, especially depression, nighttime sleep disorders such as urinary incontinence, nighttime restlessness, morning fatigue and somnolence, off-period dystonia and motor fluctuations are the variables that most affect the quality of life of patients with PD. Springer-Verlag, 2010 Parkinson's disease nationallicence Quality of life (QoL) nationallicence Sleep disorders nationallicence Depression nationallicence Gómez-Esteban Juan Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Tijero Beatriz Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Somme Johanne Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Ciordia Roberto Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Berganzo Koldo Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Rouco Idoia Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Bustos Jose Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Valle Maria Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Lezcano Elena Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Zarranz Juan Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 494-499 0340-5354 258:3<494 2011 258 415 https://doi.org/10.1007/s00415-010-5786-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5786-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gómez-Esteban Juan Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Tijero Beatriz Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Somme Johanne Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Ciordia Roberto Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Berganzo Koldo Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Rouco Idoia Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Bustos Jose Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Valle Maria Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Lezcano Elena Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Zarranz Juan Servicio de Neurología, Hospital de Cruces, Plz de Cruces sn, CP 48903, Baracaldo, Vizcaya, Spain aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 494-499 0340-5354 258:3<494 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer