caa a22 4500 445808950 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5759-1 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5759-1 Cerebral blood flow abnormalities in patients with neurally mediated syncope [Elektronische Daten] [Eun Joo, Seung Hong, Minjoo Lee, Woo Tae, James Lee, Suk Han, Ki-Hwan Ji, Minah Suh] The aim of this study is to investigate regional cerebral blood flow (rCBF) in patients with syncope. We compared brain single photon emission computed tomography (SPECT) images of neurally mediated syncope patients with those of age/sex matched healthy volunteers. 99mTc-ethylcysteinate dimer (ECD) brain SPECT was performed in 35 patients (M/F=17/18, mean 36.6years) with syncope during the asymptomatic period, and in 35 healthy volunteers. For statistical parametric mapping (SPM) analysis, all SPECT images were spatially normalized to the standard SPECT template and then smoothed using a 14-mm full width at half maximum Gaussian kernel. The mean duration of syncope history was 4.9years and the mean number of syncope episodes was 6.3. In all patients, syncope or presyncope episodes occurred during head-up tilt tests, and all were the vasodepressive type. SPM analysis of brain SPECT images showed significantly decreased rCBF in the right anterior insular cortex, left parahippocampal gyrus, bilateral fusiform gyri, bilateral middle and inferior temporal gyri, left lingual gyrus, bilateral precuneus and bilateral posterior lobes of the cerebellum in syncope patients at a false discovery rate corrected p<0.05. There were no brain regions that showed increased rCBF in syncope patients. Furthermore, we found a negative correlation between the total number of syncopal episodes and the rCBF of the right prefrontal cortex, and between the duration of syncope history and the rCBF of the right cingulate gyrus at uncorrected p<0.001. Decreases of rCBF in multiple brain regions may be responsible for autonomic dysregulation and improper processing of emotional stress in neurally mediated syncope patients, and frequent syncope episodes may lead to frontal dysfuction. Springer-Verlag, 2010 Syncope nationallicence SPECT nationallicence Cerebral blood flow nationallicence Statistical parametric mapping nationallicence Prefrontal cortex nationallicence Joo Eun Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Hong Seung Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Lee Minjoo Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Tae Woo Neuroscience Research Institute, Kangwon National University College of Medicine, Chunchon, Korea aut Lee James Department of Biochemistry, College of Arts and Sciences, University of Washington, Seattle, WA, USA aut Han Suk Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Ji Ki-Hwan Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Suh Minah Department of Biological Science, Sungkyunkwan University, Suwon, Korea aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 366-372 0340-5354 258:3<366 2011 258 415 https://doi.org/10.1007/s00415-010-5759-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5759-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Joo Eun Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Hong Seung Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Minjoo Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Tae Woo Neuroscience Research Institute, Kangwon National University College of Medicine, Chunchon, Korea aut NATIONALLICENCE 700 1- Lee James Department of Biochemistry, College of Arts and Sciences, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Han Suk Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Ji Ki-Hwan Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Suh Minah Department of Biological Science, Sungkyunkwan University, Suwon, Korea aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 366-372 0340-5354 258:3<366 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer