caa a22 4500 445808977 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5760-8 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5760-8 Validity of a computerized version of the Symbol Digit Modalities Test in multiple sclerosis [Elektronische Daten] [Nadine Akbar, Kimia Honarmand, Nancy Kou, Anthony Feinstein] The Symbol Digit Modalities Test (SDMT) is a particularly sensitive measure of cognitive dysfunction in patients with multiple sclerosis (MS). While computerized versions have been developed for use in functional magnetic resonance imaging (fMRI), none has been validated in MS patients. The aim of this study was to validate a new computerized version of the SDMT for use in MS patients. We developed a novel computerized version of the SDMT (c-SDMT) which was completed by 119 MS patients and 38 healthy controls. Our version consisted of eight timed trials of nine symbols. Both groups also underwent cognitive testing with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) which included the 90-s paper SDMT (p-SDMT) scored according to the number of correct responses per each 15-s interval. The sensitivity and specificity of the c-SDMT and p-SDMT to detect overall cognitive impairment on the BRB-N was determined. MS patients performed significantly worse than controls on both the c-SDMT (t=−6.1, p<0.001) and p-SDMT (t=5.7, p<0.001). More MS patients were impaired on the c-SDMT than the p-SDMT (37% vs. 29%). The sensitivity and specificity of the SDMT was as follows: 71% and 84%, respectively, for the c-SDMT, and 67% and 95%, respectively, for the p-SDMT. Both versions detected a significant group×time effect over the course of the individual trials, although the pattern of responses differed between them. Good test-retest reliability for the c-SDMT was shown (ICC=0.94). The results support the validity of this version of the c-SDMT as a sensitive measure of cognitive dysfunction in MS. The methodology is also fMRI compatible. Springer-Verlag, 2010 Multiple sclerosis nationallicence Cognition nationallicence Information processing speed nationallicence Symbol Digit Modalities Test nationallicence Computerized nationallicence Akbar Nadine Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut Honarmand Kimia Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut Kou Nancy Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut Feinstein Anthony Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 373-379 0340-5354 258:3<373 2011 258 415 https://doi.org/10.1007/s00415-010-5760-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5760-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akbar Nadine Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Honarmand Kimia Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Kou Nancy Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Feinstein Anthony Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 373-379 0340-5354 258:3<373 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer