caa a22 4500 445809035 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5769-z doi (NATIONALLICENCE)springer-10.1007/s00415-010-5769-z Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test [Elektronische Daten] [Yuji Tanaka, Tomohiro Kato, Hiroshi Nishida, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hiroshi Araki, Masahiko Murase, Masahito Nagaki, Hisataka Moriwaki, Takashi Inuzuka] During the pre-symptomatic stage of Parkinson's disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD, it has reported that Lewy bodies were found in the Auerbach's and Meissner's plexuses. These lesions may cause dysfunction of the gastrointestinal tract (GI) as pre-clinical symptoms of PD. However, because l-dopa therapy itself may worsen the symptoms of the digestive tract function, it is needed to evaluate the gastrointestinal tract function in patients with early-stage, untreated (de novo) PD. In the present study, using the 13C-acetate breath test (13C-ABT), we investigated gastric emptying in 20 untreated, early-stage PD patients and 40 treated, advanced-stage PD patients, and 20 healthy volunteers. Gastric emptying was examined by the 13C-ABT [the half emptying time (HET), the peak time of the 13C% dose-excess curve (T max)]. The T max and HET of gastric emptying as assessed using the 13C-ABT was significantly delayed in untreated, early-stage PD patients as compared to the controls (P<0.001). The T max and HET of gastric emptying were not significantly delayed in untreated, early-stage PD patients as compared to treated, advanced-stage PD patients. The results demonstrated that delay in gastric emptying did not differ between untreated, early-stage and treated, advanced-stage PD patients. Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD. Springer-Verlag, 2010 Parkinson's disease nationallicence Gastric emptying nationallicence Untreated (de novo) early-stage nationallicence 13C-acetate breath test nationallicence Tanaka Yuji Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Kato Tomohiro First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut Nishida Hiroshi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Yamada Megumi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Koumura Akihiro Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Sakurai Takeo Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Hayashi Yuichi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Kimura Akio Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Hozumi Isao Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Araki Hiroshi First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut Murase Masahiko First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut Nagaki Masahito First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut Moriwaki Hisataka First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut Inuzuka Takashi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 421-426 0340-5354 258:3<421 2011 258 415 https://doi.org/10.1007/s00415-010-5769-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5769-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Yuji Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Kato Tomohiro First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut NATIONALLICENCE 700 1- Nishida Hiroshi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Yamada Megumi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Koumura Akihiro Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Sakurai Takeo Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Hayashi Yuichi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Kimura Akio Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Hozumi Isao Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 700 1- Araki Hiroshi First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut NATIONALLICENCE 700 1- Murase Masahiko First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut NATIONALLICENCE 700 1- Nagaki Masahito First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut NATIONALLICENCE 700 1- Moriwaki Hisataka First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Gifu City, Japan aut NATIONALLICENCE 700 1- Inuzuka Takashi Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, 501-1194, Gifu City, Gifu Prefecture, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 421-426 0340-5354 258:3<421 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer