caa a22 4500 445809043 CHVBK 20180317145205.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00415-010-5773-3 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5773-3 Deep brain stimulation in the nucleus ventralis intermedius in patients with essential tremor: habituation of tremor suppression [Elektronische Daten] [Michael Barbe, Lena Liebhart, Matthias Runge, K. Pauls, Lars Wojtecki, Alfons Schnitzler, Niels Allert, Gereon Fink, Volker Sturm, Mohammad Maarouf, Lars Timmermann] In patients with essential tremor (ET) already treated with chronic deep brain stimulation (DBS) of the nucleus ventralis intermedius (VIM) we investigated whether optimization of stimulation parameters could improve clinical tremor suppression, and whether this putative effect could be sustained over time. Twenty-three ET patients with VIM-DBS participated in the prospective study. All electrode contacts were tested systematically and stimulation parameters were optimized over the course of 2days. Clinical tremor rating scale (TRS) was videotaped before, directly after the optimization and at a 10weeks follow-up and evaluated blindly and independently by two clinicians. For stimulation effect optimization we increased the number of active contacts whereas the total charge applied to the tissue was kept constant. TRS hemi-body scores decreased significantly after optimization. At the 10weeks follow-up, however, the improvement had faded and was no longer significant. The activities of daily living (ADL) remained significantly improved. Systematic optimization of VIM-DBS parameters in ET patients leads to a short term improvement which habituates over time. Our results provide further evidence for a tolerance effect in chronic VIM stimulation thereby suggesting that frequently alternating stimulation protocols should be tested in future studies of ET patients treated with VIM-DBS. Springer-Verlag, 2010 Essential tremor nationallicence Deep brain stimulation nationallicence Nucleus ventralis intermedius nationallicence Habituation nationallicence Tolerance nationallicence Barbe Michael Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut Liebhart Lena Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut Runge Matthias Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut Pauls K. Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut Wojtecki Lars Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany aut Schnitzler Alfons Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany aut Allert Niels Neurological Rehabilitation Center Godeshoehe, Waldstrasse 2-10, 53177, Bonn, Germany aut Fink Gereon Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut Sturm Volker Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut Maarouf Mohammad Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut Timmermann Lars Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut Journal of Neurology Springer-Verlag 258/3(2011-03-01), 434-439 0340-5354 258:3<434 2011 258 415 https://doi.org/10.1007/s00415-010-5773-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5773-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barbe Michael Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Liebhart Lena Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Runge Matthias Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Pauls K. Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Wojtecki Lars Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Schnitzler Alfons Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Allert Niels Neurological Rehabilitation Center Godeshoehe, Waldstrasse 2-10, 53177, Bonn, Germany aut NATIONALLICENCE 700 1- Fink Gereon Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 700 1- Sturm Volker Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Maarouf Mohammad Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Timmermann Lars Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/3(2011-03-01), 434-439 0340-5354 258:3<434 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer