caa a22 4500 445809078 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6014-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6014-0 Evaluation of the smooth pursuit tests in multiple sclerosis patients [Elektronische Daten] [Magdalena Jozefowicz-Korczynska, Anna Pajor] In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess the feasibility of various methods for smooth pursuit assessment: the clinical bedside examination and quantitative electrooculographic (EOG) recordings. In addition, we analyzed the effects of age on the results of smooth pursuit tests. Sixty MS patients and 50 volunteers underwent clinical bedside examination and EOG evaluation in a tertiary referral university hospital. EOG recordings of smooth pursuit tests with 0.3, 0.4, 0.5 and 15Hz amplitude and gain calculation were preformed. In clinical bedside examination, disorders were found in 25%, and with EOG in 76.6% of patients. In the MS patients and subgroups the mean gain for all frequencies were significantly lower compared with the control group. There were significant differences in gain between younger and older subjects in the control group but no significance in all MS patients their subgroups. Patients with abnormalities in clinical bedside examination had poorer results in EOG tests. There were correlations between gain values and Expanded Disability Status Scale score in MS patients. Smooth pursuit examination provides a valuable parameter of brain dysfunction in MS patients. The EOG test is more useful in detecting subclinical cases than clinical bedside examination, and is not affected by test paradigm or age in MS patients. Springer-Verlag, 2011 Multiple sclerosis nationallicence Smooth pursuit test nationallicence Bedside examination nationallicence Electrooculography nationallicence Age nationallicence Jozefowicz-Korczynska Magdalena Department of Otolaryngology, Medical University of Lodz, Barlicki University Hospital, 22, Kopcinskiego Str., 90-153, Lodz, Poland aut Pajor Anna Department of Otolaryngology, Medical University of Lodz, Barlicki University Hospital, 22, Kopcinskiego Str., 90-153, Lodz, Poland aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1795-1800 0340-5354 258:10<1795 2011 258 415 https://doi.org/10.1007/s00415-011-6014-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6014-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jozefowicz-Korczynska Magdalena Department of Otolaryngology, Medical University of Lodz, Barlicki University Hospital, 22, Kopcinskiego Str., 90-153, Lodz, Poland aut NATIONALLICENCE 700 1- Pajor Anna Department of Otolaryngology, Medical University of Lodz, Barlicki University Hospital, 22, Kopcinskiego Str., 90-153, Lodz, Poland aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1795-1800 0340-5354 258:10<1795 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer