caa a22 4500 445809116 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6036-7 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6036-7 Elevated serum level of interleukin-32α in the patients with myasthenia gravis [Elektronische Daten] [Sang-Jun Na, Seon-Hwa So, Kee Lee, Young-Chul Choi] A new cytokine, interleukin-32 (IL-32), has been implicated in the pro-inflammatory immune responses in several autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel diseases. Myasthenia gravis (MG) is a well-characterized autoimmune disease directed at the postsynaptic acetylcholine receptor (AChR) or end plate of the neuromuscular junction. IL-32 is a cytokine that induces tumor necrosis factor (TNF)-α, IL-6, IL-1β, and chemokine. IL-6, TNF-α, and IL-2 are related to the pathogenesis and immunoregulation of MG. The gene expression of IL-32 is increased in human natural killer (NK) cells and T lymphocytes when stimulated by IL-2 or mitogen. NK cells influence the development of experimental autoimmune MG (EAMG) and possibly MG. The aim of this study was to examine whether IL-32α levels are increased in patients with MG and to investigate the relationship between IL-32α levels and disease activity in human MG. Serum IL-32α levels were significantly higher in the MG patients (p=0.03): 460.07±192.30pg/mL in MG patients and 248.45±188.42pg/mL in the healthy control group. Although there was no significant statistical difference, serum IL-32α levels of patients with both anti-AChR binding and blocking antibodies trended to be higher than those without either antibodies (521.56±212.92pg/mL vs. 339.52±182.78pg/mL, p=0.16). IL-32α serum levels tended to decrease with clinical improvement in generalized MG. This study suggests the possibility that IL-32 might contribute to MG pathogenesis or immunoregulation. Springer-Verlag, 2011 Interleukin-32α (IL-32α) nationallicence Autoimmune disorder nationallicence Myasthenia gravis (MG) nationallicence Natural killer cell (NK) nationallicence Na Sang-Jun Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut So Seon-Hwa Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut Lee Kee Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut Choi Young-Chul Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1865-1870 0340-5354 258:10<1865 2011 258 415 https://doi.org/10.1007/s00415-011-6036-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6036-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Na Sang-Jun Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- So Seon-Hwa Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Kee Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Choi Young-Chul Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 146-92 Gangnam-gu, 135-720, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1865-1870 0340-5354 258:10<1865 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer