caa a22 4500 445809183 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6104-z doi (NATIONALLICENCE)springer-10.1007/s00415-011-6104-z The role of mitochondria in neurodegenerative diseases [Elektronische Daten] [Massimiliano Filosto, Mauro Scarpelli, Maria Cotelli, Valentina Vielmi, Alice Todeschini, Valeria Gregorelli, Paola Tonin, Giuliano Tomelleri, Alessandro Padovani] Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field. Springer-Verlag, 2011 Alzheimer's disease nationallicence Amyotrophic lateral sclerosis nationallicence Huntington disease nationallicence Inclusion body myopathy nationallicence Mitochondria nationallicence mtDNA nationallicence Neurodegenerative disorders nationallicence Parkinson's disease nationallicence Filosto Massimiliano Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Scarpelli Mauro Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut Cotelli Maria Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Vielmi Valentina Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Todeschini Alice Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Gregorelli Valeria Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Tonin Paola Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut Tomelleri Giuliano Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut Padovani Alessandro Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1763-1774 0340-5354 258:10<1763 2011 258 415 https://doi.org/10.1007/s00415-011-6104-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6104-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Filosto Massimiliano Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 700 1- Scarpelli Mauro Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Cotelli Maria Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 700 1- Vielmi Valentina Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 700 1- Todeschini Alice Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 700 1- Gregorelli Valeria Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 700 1- Tonin Paola Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Tomelleri Giuliano Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Padovani Alessandro Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1763-1774 0340-5354 258:10<1763 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer