caa a22 4500 445809191 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6029-6 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6029-6 Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study [Elektronische Daten] [Sebastian Paus, Jennifer Gross, Martina Moll-Müller, Frank Hentschel, Annika Spottke, Bettina Wabbels, Thomas Klockgether, Michael Abele] While sleep disorders are common in Parkinson's disease and other basal ganglia disorders, information on sleep disturbances in dystonia is limited to generalized forms or Segawa disease. Although many patients with idiopathic cervical dystonia (CD) and blepharospasm (BL) report poor sleep, there are no data on frequency or interactions with well known symptoms like depression and pain. Standardized interviews and assessment instruments, clinical examinations, and self rating forms were applied in 221 patients with CD and BL, and in 93 neurologically healthy controls. Impaired sleep quality was found in 44% of CD patients, 46% of BL patients, and 20% of controls. In dystonia, it was associated with symptoms of depression (frequency of 26%; p<0.001) and restless legs syndrome (RLS) (frequency of 19%; p<0.01). Bruxism (in CD; p<0.05), and female sex (in BL; p<0.001) were identified as further risk factors, but not severity of dystonic symptoms. Excessive daytime sleepiness was rare in CD and BL (6%). With a frequency of 45%, impairment of sleep quality is common in focal dystonia and associated with symptoms of depression, bruxism, and RLS. Results in CD and BL patients are similar, pointing to an intrinsic mechanism of sleep disturbances rather than a direct effect of dystonic muscle activity. Further studies on sleep in focal dystonia, including polysomnographic recordings, are warranted. Springer-Verlag, 2011 Focal dystonia nationallicence Sleep quality nationallicence Sleep disorders nationallicence Depression nationallicence Restless legs syndrome nationallicence Paus Sebastian Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Gross Jennifer Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Moll-Müller Martina Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Hentschel Frank Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Spottke Annika Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Wabbels Bettina Department of Ophthalmology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Klockgether Thomas Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Abele Michael Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1835-1840 0340-5354 258:10<1835 2011 258 415 https://doi.org/10.1007/s00415-011-6029-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6029-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paus Sebastian Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Gross Jennifer Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Moll-Müller Martina Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Hentschel Frank Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Spottke Annika Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Wabbels Bettina Department of Ophthalmology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Klockgether Thomas Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 700 1- Abele Michael Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1835-1840 0340-5354 258:10<1835 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer