caa a22 4500 44580923X CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6028-7 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6028-7 Cost-of-illness in multiple system atrophy and progressive supranuclear palsy [Elektronische Daten] [Yaroslav Winter, Maria Stamelou, Nicole Cabanel, Friedericke Sixel-Döring, Karla Eggert, Günter Höglinger, Birgit Herting, Thomas Klockgether, Heinz Reichmann, Wolfgang Oertel, Richard Dodel, Annika Spottke] Multiple system atrophy and progressive supranuclear palsy are disabling neurodegenerative disorders, also known as atypical parkinsonian syndromes. Currently, no health economic evaluations of these diseases are available. The objective of this study was to evaluate disease-related costs in German patients with multiple system atrophy and progressive supranuclear palsy and to identify cost-driving factors. We recruited 101 consecutive patients with multiple system atrophy (n=54) and progressive supranuclear palsy (n=47) in four German specialised movement disorder clinics. The health economic data were collected using comprehensive health economic questionnaires ("bottom-up” approach). Costs were calculated from the societal perspective in 2010 Euros. Independent cost-driving factors were identified in multiple regression analysis. The total semi-annual costs of atypical parkinsonian syndromes were EUR 16,670 (95% CI: 13,470-21,850). Direct costs accounted for 73% (inpatient care 31%, special equipment 24%, copayments of patients 21%, others 24%) and indirect costs for 27% of total costs. The economic burden imposed on patients by atypical parkinsonian syndromes accounted for 36% of their income. Independent cost-driving factors were younger age, disease severity, living without a partner and depression. The disease-related costs of atypical parkinsonian syndromes in Germany are high and above the costs reported for idiopathic Parkinson's disease. Disease-specific patterns of cost distributions in atypical parkinsonian syndromes and independent cost-drivers should be considered in future health economic evaluations and healthcare programs. The early diagnosis and treatment of depression in patients with atypical parkinsonian syndromes as well as programs aimed to improve social support will reduce disease-related costs. Springer-Verlag, 2011 Atypical parkinsonian disorders nationallicence Progressive supranuclear palsy nationallicence Multiple system atrophy nationallicence Costs nationallicence Winter Yaroslav Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Stamelou Maria Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Cabanel Nicole Department of Psychiatry, Philipps-University Marburg, Marburg, Germany aut Sixel-Döring Friedericke Center of Parkinsonism and Movement Disorders, Paracelsus-Elena Hospital, Kassel, Germany aut Eggert Karla Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Höglinger Günter Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Herting Birgit Department of Neurology, University of Technology Dresden, Dresden, Germany aut Klockgether Thomas Department of Neurology, Friedrich-Wilhelms-University Bonn, Bonn, Germany aut Reichmann Heinz Department of Neurology, University of Technology Dresden, Dresden, Germany aut Oertel Wolfgang Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Dodel Richard Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut Spottke Annika Department of Neurology, Friedrich-Wilhelms-University Bonn, Bonn, Germany aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1827-1834 0340-5354 258:10<1827 2011 258 415 https://doi.org/10.1007/s00415-011-6028-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6028-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winter Yaroslav Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Stamelou Maria Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Cabanel Nicole Department of Psychiatry, Philipps-University Marburg, Marburg, Germany aut NATIONALLICENCE 700 1- Sixel-Döring Friedericke Center of Parkinsonism and Movement Disorders, Paracelsus-Elena Hospital, Kassel, Germany aut NATIONALLICENCE 700 1- Eggert Karla Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Höglinger Günter Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Herting Birgit Department of Neurology, University of Technology Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Klockgether Thomas Department of Neurology, Friedrich-Wilhelms-University Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Reichmann Heinz Department of Neurology, University of Technology Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Oertel Wolfgang Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Dodel Richard Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Spottke Annika Department of Neurology, Friedrich-Wilhelms-University Bonn, Bonn, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1827-1834 0340-5354 258:10<1827 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer