caa a22 4500 445809302 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00415-011-6030-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6030-0 In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings [Elektronische Daten] [Maïté Formaglio, Nicolas Costes, Jérémie Seguin, Yannick Tholance, Didier Le Bars, Isabelle Roullet-Solignac, Bernadette Mercier, Pierre Krolak-Salmon, Alain Vighetto] Our objective was to evaluate amyloid deposition in posterior cortical atrophy (PCA), using both cerebrospinal fluid (CSF) biomarker analysis and amyloid imaging. Five PCA patients, selected based on their neuropsychological profile and atrophic changes in posterior regions on MRI, underwent CSF analysis. CSF amyloid-beta 1-42, total tau, and phosphorylated tau at threonine 181 levels were determined. They also had positron emission tomography (PET) with Pittsburgh Compound B ([11C]PIB). [11C]PIB ratio images were assessed with visual, regional and voxel-based analyses and compared to eight typical Alzheimer's disease (AD) patients and eight controls. The biological profile in the five PCA patients, resulting from CSF and [11C]PIB images analysis, was consistent with AD. Individual comparisons of PCA patients' [11C]PIB images with the AD group with Statistical Parametric Mapping (SPM) revealed a distinctive posterior uptake in four out of the five patients showing increased amyloid deposition in occipital, temporal, and/or parietal regions. ROI group analysis showed a tendency for higher amyloid deposition in occipital and temporal regions. However, this pattern was not found with SPM group analysis when the global level of [11C]PIB uptake was used as a covariate. Our results indicate that amyloid burden can be demonstrated in vivo in PCA suggesting a diagnosis of AD. PCA patients may present a higher global amyloid load than AD that was not related to age at onset, disease severity, disease duration, or educational level in our study. Combined CSF and PET biomarkers seem helpful for in vivo diagnosis of this focal syndrome with underlying AD pathology. Springer-Verlag, 2011 Posterior cortical atrophy nationallicence Pittsburgh Compound B nationallicence PET nationallicence Voxel based analysis nationallicence CSF biomarkers nationallicence Alzheimer's disease nationallicence Formaglio Maïté Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut Costes Nicolas CERMEP, Imagerie du vivant, 59 boulevard Pinel, 69003, Lyon, France aut Seguin Jérémie Neurobiology Laboratory, Department of Biochemistry, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Est, 59 boulevard Pinel, 69003, Lyon, France aut Tholance Yannick Neurobiology Laboratory, Department of Biochemistry, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Est, 59 boulevard Pinel, 69003, Lyon, France aut Le Bars Didier CERMEP, Imagerie du vivant, 59 boulevard Pinel, 69003, Lyon, France aut Roullet-Solignac Isabelle Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut Mercier Bernadette Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut Krolak-Salmon Pierre Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut Vighetto Alain Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1841-1851 0340-5354 258:10<1841 2011 258 415 https://doi.org/10.1007/s00415-011-6030-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6030-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Formaglio Maïté Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Costes Nicolas CERMEP, Imagerie du vivant, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Seguin Jérémie Neurobiology Laboratory, Department of Biochemistry, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Est, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Tholance Yannick Neurobiology Laboratory, Department of Biochemistry, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Est, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Le Bars Didier CERMEP, Imagerie du vivant, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Roullet-Solignac Isabelle Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Mercier Bernadette Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Krolak-Salmon Pierre Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 700 1- Vighetto Alain Department of Neurology, Service de Neurologie D, Hospices Civils de Lyon, Hôpital Neurologique, 59 boulevard Pinel, 69003, Lyon, France aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/10(2011-10-01), 1841-1851 0340-5354 258:10<1841 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer