caa a22 4500 445809353 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-011-5952-x doi (NATIONALLICENCE)springer-10.1007/s00415-011-5952-x Parkinson's disease risk score: moving to a premotor diagnosis [Elektronische Daten] [Jürgen Winkler, Reinhard Ehret, Thomas Büttner, Ulrich Dillmann, Wolfgang Fogel, Michael Sabolek, Juliane Winkelmann, Jan Kassubek] Early pre-motor symptoms (also frequently termed "non-motor” symptoms) in Parkinson's disease (PD), which precede the onset of motor symptoms, are being increasingly recognized by clinicians. Non-motor symptoms in the pre-motor phase of PD include impaired olfaction (hyposmia), sleep disturbances (i.e., radid eye movement sleep behavior disorder, daytime sleepiness), behavioral/emotional dysfunction (i.e., change of personality or change of core personal characteristics), dysautonomia (i.e., constipation, urinary dysfunction, orthostatic hypotension), depressive symptoms (i.e., fatigue, apathy, anxiety), and chronic pain (joint and muscle). The pre-motor phase of PD is based on current pathophysiological concepts that relate these symptoms to early structural changes within lower brainstem nuclei and the peripheral nervous system including the autonomic and enteric ganglia. The perspective to identify these symptoms as early as possible will enable neurologists to make a diagnosis at the pre-motor stage of PD. Thus, the development of a PD risk score will be the first means to identify individuals at risk who are most likely to develop the prototypical motor symptoms of PD later in life. More importantly, these individuals at risk will be the first to benefit from disease-modifying strategies. In this workshop report, the elements of a PD risk score are proposed, including the stepwise sequence of escalating diagnostic measures to diagnose the pre-motor stage in PD. Springer-Verlag, 2011 Parkinsonian syndrome nationallicence Diagnosis nationallicence Neuroimaging nationallicence Non-motor symptoms nationallicence Therapy nationallicence Winkler Jürgen Division of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Ehret Reinhard Neuro-Zentrum Steglitz, Berlin, Germany aut Büttner Thomas Department of Neurology, Klinikum Emden, Emden, Germany aut Dillmann Ulrich Department of Neurology, University of Saarland, Homburg/Saar, Germany aut Fogel Wolfgang Neurological Department, DKD, Wiesbaden, Germany aut Sabolek Michael Neurological Clinic Dietenbronn, Schwendi, Germany aut Winkelmann Juliane Neurologische Klinik und Institut Humangenetik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany aut Kassubek Jan Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Journal of Neurology Springer-Verlag 258(2011-05-01), 311-315 0340-5354 258<311 2011 258 415 https://doi.org/10.1007/s00415-011-5952-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5952-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winkler Jürgen Division of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Ehret Reinhard Neuro-Zentrum Steglitz, Berlin, Germany aut NATIONALLICENCE 700 1- Büttner Thomas Department of Neurology, Klinikum Emden, Emden, Germany aut NATIONALLICENCE 700 1- Dillmann Ulrich Department of Neurology, University of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Fogel Wolfgang Neurological Department, DKD, Wiesbaden, Germany aut NATIONALLICENCE 700 1- Sabolek Michael Neurological Clinic Dietenbronn, Schwendi, Germany aut NATIONALLICENCE 700 1- Winkelmann Juliane Neurologische Klinik und Institut Humangenetik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany aut NATIONALLICENCE 700 1- Kassubek Jan Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258(2011-05-01), 311-315 0340-5354 258<311 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer