caa a22 4500 445809396 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-011-6040-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-6040-y Basic science in Parkinson's disease: its impact on clinical practice [Elektronische Daten] [Jörg Schulz, Manfred Gerlach, Gabriele Gille, Wilfried Kuhn, Martina Müngersdorf, Peter Riederer, Martin Südmeyer, Albert Ludolph] Failures in clinical studies that were aimed to prove disease-modifying effects of treatments in Parkinson's disease (PD) raise the question as to whether basic sciences have had an impact in clinical practice. This question implies that despite well-publicized results obtained by intensive genetic and pathogenetic research, e.g. the identification of mutations and cellular biochemical pathways that underlie Parkinson-specific neurodegeneration, no relevant disease-modifying treatment options have been developed. This view neglects the fact that today there are plenty of dopaminergic and non-dopaminergic and surgical treatment options, and that PD was not treatable 50years ago. This progress was made possible only by basic science. In this review, we underline the success of previous basic science for daily practice in PD and its impact for the understanding and development of an early diagnosis. Early, even pre-symptomatic diagnosis might be key to successfully establish disease-modifying treatments. Springer-Verlag, 2011 Parkinson's disease nationallicence Basic science nationallicence History nationallicence Treatment nationallicence Genetics nationallicence Schulz Jörg Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Gerlach Manfred Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany aut Gille Gabriele Department of Neurology, TU Dresden, Dresden, Germany aut Kuhn Wilfried Department of Neurology, Leopoldina-Krankenhaus, Schweinfurt, Germany aut Müngersdorf Martina Neurologie am Hackeschen Markt, Berlin, Germany aut Riederer Peter Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany aut Südmeyer Martin Department of Neurology, University of Düsseldorf, Düsseldorf, Germany aut Ludolph Albert Department of Neurolgy, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Journal of Neurology Springer-Verlag 258(2011-05-01), 299-306 0340-5354 258<299 2011 258 415 https://doi.org/10.1007/s00415-011-6040-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6040-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schulz Jörg Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Gerlach Manfred Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Gille Gabriele Department of Neurology, TU Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Kuhn Wilfried Department of Neurology, Leopoldina-Krankenhaus, Schweinfurt, Germany aut NATIONALLICENCE 700 1- Müngersdorf Martina Neurologie am Hackeschen Markt, Berlin, Germany aut NATIONALLICENCE 700 1- Riederer Peter Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Südmeyer Martin Department of Neurology, University of Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Ludolph Albert Department of Neurolgy, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258(2011-05-01), 299-306 0340-5354 258<299 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer