caa a22 4500 445809418 CHVBK 20180317145206.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-011-5974-4 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5974-4 Stem cell-based therapies in Parkinson's disease: future hope or current treatment option? [Elektronische Daten] [Kai Loewenbrück, Alexander Storch] Parkinson's disease (PD) is one of the most frequent neurodegenerative diseases and represents a major therapeutic challenge because of the so far missing therapeutic means to influence the ongoing loss of dopaminergic innervation to the striatum. Cell replacement has raised hope to offer the first restorative treatment option. Clinical trials have provided "proof of principle” that transplantation of dopamine-producing neurons into the striatum of PD patients can achieve symptomatic relief given that the striatum is sufficiently re-innervated. Various cell sources have been tested, including fetal ventral midbrain tissue, embryonic stem cells, fetal and adult neural stem cells and, after a ground-breaking discovery, induced pluripotent stem cells. Although embryonic and induced pluripotent stem cells have emerged as the most promising candidates to overcome most of the obstacles to clinical successful cell replacement, each cell source has its unique drawbacks. This review does not only provide a comprehensive overview of the different cellular candidates, including their assets and drawbacks, but also of the various additional issues that need to be addressed in order to convert cellular replacement therapies from an experimental to a clinically relevant therapeutic alternative. Springer-Verlag, 2011 Embryonic stem cells nationallicence Induced pluripotent stem cells nationallicence Neural stem cells nationallicence Parkinson's disease nationallicence Neurotransplantation nationallicence Neuroregeneration nationallicence Loewenbrück Kai Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany aut Storch Alexander Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany aut Journal of Neurology Springer-Verlag 258(2011-05-01), 346-353 0340-5354 258<346 2011 258 415 https://doi.org/10.1007/s00415-011-5974-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5974-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loewenbrück Kai Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Storch Alexander Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258(2011-05-01), 346-353 0340-5354 258<346 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer