caa a22 4500 445809426 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-011-6016-y doi (NATIONALLICENCE)springer-10.1007/s00415-011-6016-y Schapira Anthony University Department of Clinical Neurosciences, Institute of Neurology, University College London, Rowland Hill Street, NW3 2PF, London, UK aut Aetiopathogenesis of Parkinson's disease [Elektronische Daten] [Anthony Schapira] Parkinson's disease (PD) is characterised both clinically and pathologically by features that distinguish it from other parkinsonian disorders including, for instance, multiple system atrophy and progressive supranuclear palsy. The aetiologies of PD includes both genetic and environmental influences. Several single gene causes of autosomal dominant and recessive PD have been described. Recent genome-wide association (GWA) studies have identified a number of risk alleles for PD. No specific environmental cause has been defined but several factors have been described which influence the risk for PD. Mitochondrial dysfunction, free radical mediated damage, inflammatory change and proteasomal dysfunction have been thought to play a role in PD pathogenesis. Autophagy is now recognised as an important component of the cell's mechanism for protein turnover and has relevance for PD. There is some convergence and overlap of pathogenetic pathways between environmental and genetic factors. The importance of identifying the molecular and biochemical events that lead to PD lies in the prospect that novel drug targets will emerge and that new compounds will be developed that slow the progression of the disease. Springer-Verlag, 2011 Parkinson's disease nationallicence Mitochondria nationallicence Oxidative stress nationallicence Autophagy nationallicence Mitophagy nationallicence Journal of Neurology Springer-Verlag 258(2011-05-01), 307-310 0340-5354 258<307 2011 258 415 https://doi.org/10.1007/s00415-011-6016-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6016-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schapira Anthony University Department of Clinical Neurosciences, Institute of Neurology, University College London, Rowland Hill Street, NW3 2PF, London, UK aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258(2011-05-01), 307-310 0340-5354 258<307 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer