caa a22 4500 445809450 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5799-6 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5799-6 Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis [Elektronische Daten] [Susanne Mueller, Andreas Ebel, Jerome Barakos, Cathy Scanlon, Ian Cheong, Daniel Finlay, Paul Garcia, Michael Weiner, Kenneth Laxer] MR spectroscopy has demonstrated extrahippocampal NAA/(Cr+Cho) reductions in medial temporal lobe epilepsy with (TLE-MTS) and without (TLE-no) mesial temporal sclerosis. Because of the limited brain coverage of those previous studies, it was, however, not possible to assess differences in the distribution and extent of these abnormalities between TLE-MTS and TLE-no. This study used a 3D whole brain echoplanar spectroscopic imaging (EPSI) sequence to address the following questions: (1) Do TLE-MTS and TLE-no differ regarding severity and distribution of extrahippocampal NAA/(Cr+Cho) reductions? (2) Do extrahippocampal NAA/(Cr+Cho) reductions provide additional information for focus lateralization? Forty-three subjects (12 TLE-MTS, 13 TLE-no, 18 controls) were studied with 3D EPSI. Statistical parametric mapping (SPM2) was used to identify regions of significantly decreased NAA/(Cr+Cho) in TLE groups and in individual patients. TLE-MTS and TLE-no had widespread extrahippocampal NAA/(Cr+Cho) reductions. NAA/(Cr+Cho) reductions had a bilateral fronto-temporal distribution in TLE-MTS and a more diffuse, less well defined distribution in TLE-no. Extrahippocampal NAA/(Cr+Cho) decreases in the single subject analysis showed a large inter-individual variability and did not provide additional focus lateralizing information. Extrahippocampal NAA/(Cr+Cho) reductions in TLE-MTS and TLE-no are neither focal nor homogeneous. This reduces their value for focus lateralization and suggests a heterogeneous etiology of extrahippocampal spectroscopic metabolic abnormalities in TLE. The Author(s), 2010 Temporal lobe epilepsy nationallicence Mesial temporal sclerosis nationallicence NAA nationallicence Spectroscopy nationallicence Mueller Susanne Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Ebel Andreas Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Barakos Jerome Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, CA, USA aut Scanlon Cathy Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Cheong Ian Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Finlay Daniel Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Garcia Paul Department of Neurology, University of California, San Francisco, CA, USA aut Weiner Michael Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut Laxer Kenneth Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, CA, USA aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 603-612 0340-5354 258:4<603 2011 258 415 https://doi.org/10.1007/s00415-010-5799-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5799-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mueller Susanne Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Ebel Andreas Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Barakos Jerome Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Scanlon Cathy Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Cheong Ian Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Finlay Daniel Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Garcia Paul Department of Neurology, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Weiner Michael Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Laxer Kenneth Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 603-612 0340-5354 258:4<603 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer