caa a22 4500 445809515 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5805-z doi (NATIONALLICENCE)springer-10.1007/s00415-010-5805-z Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis [Elektronische Daten] [J. Dorst, P. Kühnlein, C. Hendrich, J. Kassubek, A. Sperfeld, A. Ludolph] Weight loss is a common phenomenon and an independent prognostic factor in amyotrophic lateral sclerosis (ALS). Several potential causal mechanisms, including intrinsic hypermetabolism and deficient food intake, have been discussed. We investigated the influence of fasting serum glucose, cholesterol, and triglyceride levels at time of diagnosis on survival in ALS. Serum cholesterol (LDL, HDL, and LDL/HDL ratio), triglycerides, and glucose were investigated in 488 patients (age of onset=57.6±12.6years) in relation to survival and revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALS-FRS) data. High serum levels of both fasting cholesterol and triglycerides had a significantly positive effect on survival (p<0.05). We found a median prolonged life expectancy by 14months for patients with serum triglyceride levels above the median of 1.47mmol/l. The results suggest that the lipid metabolism and the nutritional status of ALS patients are important prognostic factors. These parameters should be thoroughly monitored during the clinical management of these patients. In case of progressive loss of body weight, a diet rich in lipids and calories should be considered. However, the final decision whether a lipid-rich diet should be recommended to ALS patients can only be based on a double-blind placebo-controlled interventional trial. Our results further imply that lipid-lowering drugs, e.g., statins, should be applied carefully in ALS patients although individual risk considerations must be made. Springer-Verlag, 2010 Amyotrophic lateral sclerosis nationallicence Fat metabolism nationallicence Nutrition nationallicence Dorst J. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Kühnlein P. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Hendrich C. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Kassubek J. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Sperfeld A. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Ludolph A. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 613-617 0340-5354 258:4<613 2011 258 415 https://doi.org/10.1007/s00415-010-5805-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5805-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dorst J. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Kühnlein P. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Hendrich C. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Kassubek J. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Sperfeld A. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Ludolph A. Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 613-617 0340-5354 258:4<613 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer