caa a22 4500 445809558 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5810-2 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5810-2 Urinary symptoms and urodynamic findings in patients with Machado-Joseph disease [Elektronische Daten] [André Musegante, Priscila Almeida, André Barboza, Ubirajara Barroso Jr] The study evaluated the prevalence of clinical and urodynamic findings in the lower urinary tract of patients with Machado-Joseph (MJ) disease. One hundred twenty-two patients were retrospectively evaluated; 17 (13.9%) presented lower urinary tract dysfunction, 10 of them were women. The average age was 41.6years. Urgency was found in 15 patients and incontinence in nine. The urodynamic study showed detrusor overactivity in eight patients, areflexia in one, and four with normal detrusor contractility. Bladder sensitivity was abnormal in six, bladder capacity was decreased in one, urine flow decreased in 13, post-voiding residue was greater than 100ml in nine. We could not find sphincter dyssynergia. The average cytosine-adenine-guanine (CAG) repetition was higher in patients with abnormal detrusor contraction (89.9) than in patients with normal urodynamics (68.2) (p=0.03). There was no statistical significance when comparing the averages of replicates for people with and without urgency urinary incontinence (p=0.27 and p=0.5, respectively). The rate of lower urinary tract dysfunction in patients with MJ disease was around 14%. The urodynamic study showed predominance of detrusor overactivity and urgency as the most common symptom. We found an association between the total number of CAG repetitions and changes in detrusor contractility. Springer-Verlag, 2010 Machado-Joseph disease nationallicence Urinary bladder, neurogenic nationallicence Urodynamics nationallicence Genetics nationallicence Musegante André SARAH Network of Rehabilitation Hospitals, Av. Tancredo Neves, 2782, Caminho das Árvores, 41820-900, Salvador, Bahia, Brazil aut Almeida Priscila SARAH Network of Rehabilitation Hospitals, Av. Tancredo Neves, 2782, Caminho das Árvores, 41820-900, Salvador, Bahia, Brazil aut Barboza André SARAH Network of Rehabilitation Hospitals, Brasília, Brazil aut Barroso Jr Ubirajara Bahiana University of Bahia, Salvador, Brazil aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 623-626 0340-5354 258:4<623 2011 258 415 https://doi.org/10.1007/s00415-010-5810-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5810-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Musegante André SARAH Network of Rehabilitation Hospitals, Av. Tancredo Neves, 2782, Caminho das Árvores, 41820-900, Salvador, Bahia, Brazil aut NATIONALLICENCE 700 1- Almeida Priscila SARAH Network of Rehabilitation Hospitals, Av. Tancredo Neves, 2782, Caminho das Árvores, 41820-900, Salvador, Bahia, Brazil aut NATIONALLICENCE 700 1- Barboza André SARAH Network of Rehabilitation Hospitals, Brasília, Brazil aut NATIONALLICENCE 700 1- Barroso Jr Ubirajara Bahiana University of Bahia, Salvador, Brazil aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 623-626 0340-5354 258:4<623 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer