caa a22 4500 445809566 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-011-5962-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5962-8 Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients [Elektronische Daten] [Heidi Ormstad, Hans Aass, Karl-Friedrich Amthor, Niels Lund-Sørensen, Leiv Sandvik] Fatigue is a common but often overlooked symptom after stroke. This study investigated whether stroke type, infarct volume, and laterality, as well as the levels of various cytokines and other blood components in the acute phase of acute ischemic stroke (AIS), can predict the level of fatigue at 6, 12, and 18months after its onset. In 45 patients with acute stroke, serum levels of C-reactive protein, hemoglobin, glucose, and 13 cytokines were measured within 72h of stroke onset. The cytokine measurements were performed using BioPlex XMap technology (Luminex). The acute serum levels of interleukin (IL)-1β and glucose were positively correlated with the score on the Fatigue Severity Scale (FSS) at 6months after the stroke (r=0.37, p=0.015, and r=0.37, p=0.017, respectively). The acute serum levels of IL-ra and IL-9 were negatively correlated with FSS score at 12months after the stroke (r=−0.38, p=0.013, and r=−0.36, p=0.019, respectively). The FSS score at 12months after stroke was significantly lower in patients with radiologically confirmed infarction than in those without such confirmation (p=0.048). The FSS score at 18months was not correlated with any of the measured variables. High acute serum levels of glucose and IL-1β, and low IL1-ra and IL-9 may predict fatigue after AIS, indicating that the development of poststroke fatigue can be accounted for by the proinflammatory response associated with AIS. These novel findings support a new cytokine theory of fatigue after stroke. However, more research is needed to validate the results of this study. The Author(s), 2011 Acute ischemic stroke nationallicence Inflammation nationallicence Cytokines nationallicence Proinflammatory nationallicence Anti-inflammatory nationallicence Ormstad Heidi Vestre Viken Hospital Trust, Ringerike, Servicebox 13, 3530, Hønefoss, Norway aut Aass Hans The R & D Group, Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway aut Amthor Karl-Friedrich Department of Neurology, Vestre Viken Hospital Trust, Buskerud, Norway aut Lund-Sørensen Niels Department of Radiology, Vestre Viken Hospital Trust, Buskerud, Norway aut Sandvik Leiv Section of Biostatistics, Oslo University Hospital, Ullevål, Oslo, Norway aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 670-676 0340-5354 258:4<670 2011 258 415 https://doi.org/10.1007/s00415-011-5962-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5962-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ormstad Heidi Vestre Viken Hospital Trust, Ringerike, Servicebox 13, 3530, Hønefoss, Norway aut NATIONALLICENCE 700 1- Aass Hans The R & D Group, Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway aut NATIONALLICENCE 700 1- Amthor Karl-Friedrich Department of Neurology, Vestre Viken Hospital Trust, Buskerud, Norway aut NATIONALLICENCE 700 1- Lund-Sørensen Niels Department of Radiology, Vestre Viken Hospital Trust, Buskerud, Norway aut NATIONALLICENCE 700 1- Sandvik Leiv Section of Biostatistics, Oslo University Hospital, Ullevål, Oslo, Norway aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 670-676 0340-5354 258:4<670 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer