caa a22 4500 445809582 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-011-6006-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6006-0 Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume [Elektronische Daten] [Heidi Ormstad, Hans Aass, Niels Lund-Sørensen, Karl-Friedrich Amthor, Leif Sandvik] There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, type, and infarct volume. Forty-five patients with AIS were evaluated. Blood samples were taken within 72h, and volumetric analyses performed within 1-7days after AIS onset. Cytokines were measured in serum from all patients and from 40 control subjects using Luminex Bio-Plex XMap technology. The levels of interleukin (IL)-1ra (p<0.001), IL-6 (p<0.001), IL-8 (p<0.001), IL-9 (p=0.038), IL-10 (p=0.001), IL-12 (p=0.001), IL-18 (p<0.001), and GRO-α (CXCL1) (p=0.017) were significantly higher in the AIS patients than in the controls. The IL-8 level was significantly correlated with age in the patient group (r=0.52, p<0.001). None of the variables were found to be associated with stroke lateralization. Infarct volume was significantly positively correlated with CRP level (r=0.47, p=0.005). Patients with radiologically confirmed infarctions had significantly elevated serum levels of GRO-α (p=0.023). The cytokine profile of the AIS patients supports not only earlier findings of a proinflammatory response but also early activation of endogenous immunosuppressive mechanisms. Novel findings of this study are elevated serum levels of IL-9 and GRO-α. Elevated GRO-α in AIS patients with radiologically confirmed infarctions suggests that GRO-α is specific for stroke of known etiology. Our results indicate that CRP plays an important role in the progression of cerebral tissue injury. The Author(s), 2011 Acute ischemic stroke nationallicence Inflammation nationallicence Cytokines nationallicence Proinflammatory nationallicence Anti-inflammatory nationallicence Ormstad Heidi Vestre Viken Hospital Trust, Bærum sykehus, Postbox 83, 1309, Rud, Norway aut Aass Hans The R & D Group, Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway aut Lund-Sørensen Niels Department of Radiology, Vestre Viken Hospital Trust, Buskerud, Norway aut Amthor Karl-Friedrich Department of Neurology, Vestre Viken Hospital Trust, Buskerud, Norway aut Sandvik Leif Section of Biostatistics, Oslo University Hospital, Ullevål, Oslo, Norway aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 677-685 0340-5354 258:4<677 2011 258 415 https://doi.org/10.1007/s00415-011-6006-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6006-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ormstad Heidi Vestre Viken Hospital Trust, Bærum sykehus, Postbox 83, 1309, Rud, Norway aut NATIONALLICENCE 700 1- Aass Hans The R & D Group, Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway aut NATIONALLICENCE 700 1- Lund-Sørensen Niels Department of Radiology, Vestre Viken Hospital Trust, Buskerud, Norway aut NATIONALLICENCE 700 1- Amthor Karl-Friedrich Department of Neurology, Vestre Viken Hospital Trust, Buskerud, Norway aut NATIONALLICENCE 700 1- Sandvik Leif Section of Biostatistics, Oslo University Hospital, Ullevål, Oslo, Norway aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 677-685 0340-5354 258:4<677 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer