caa a22 4500 445809604 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5812-0 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5812-0 Spontaneous pain, pain threshold, and pain tolerance in Parkinson's disease [Elektronische Daten] [Sandro Zambito Marsala, Michele Tinazzi, Roberta Vitaliani, Serena Recchia, Federico Fabris, Corrado Marchini, Antonio Fiaschi, Giuseppe Moretto, Bruno Giometto, Antonella Macerollo, Giovanni Defazio] The mechanisms underlying pain in Parkinson's disease (PD) are unclear. Although a few studies have reported that PD patients may have low pain threshold and tolerance, none could accurately assess whether there was a correlation between sensory thresholds and demographic/clinical features of PD patients. Thus, tactile threshold, pain threshold, and pain tolerance to electrical stimuli in the hands and feet were assessed in 106 parkinsonian patients (of whom 66 reported chronic pain) and 51 age- and sex-matched healthy subjects. Linear regression models determined relationships between psychophysical parameters and demographic/clinical features. Female gender, severity of disease, medical disease associated with painful symptoms, and dyskinesia were more frequently observed in PD patients experiencing pain, even though dyskinesia did not reach significance. Pain threshold and pain tolerance were significantly lower in PD patients than in control subjects, whereas the tactile threshold yielded comparable values in both groups. Multivariable linear regression analyses yielded significant inverse correlations of pain threshold and pain tolerance with motor symptom severity and Beck depression inventory. Pain threshold and pain tolerance did not differ between PD patients with and without pain. In the former group, there was no relationship between pain threshold and the intensity/type of pain, and number of painful body parts. These findings suggest that pain threshold and pain tolerance tend to decrease as PD progresses, which can predispose to pain development. Female gender, dyskinesia, medical conditions associated with painful symptoms, and postural abnormalities secondary to rigidity/bradikinesia may contribute to the appearance of spontaneous pain in predisposed subjects. Springer-Verlag, 2010 Parkinson's disease nationallicence Pain nationallicence Pain threshold nationallicence Pain tolerance nationallicence Zambito Marsala Sandro Neurology Unit, San Martino Hospital, Belluno, Italy aut Tinazzi Michele Department of Neurosciences, University of Verona, Verona, Italy aut Vitaliani Roberta Neurology Unit, Cà Foncello Hospital, Treviso, Italy aut Recchia Serena Department of Neurosciences, University of Verona, Verona, Italy aut Fabris Federico Neurology Unit, San Martino Hospital, Belluno, Italy aut Marchini Corrado Neurology Unit, San Martino Hospital, Belluno, Italy aut Fiaschi Antonio Department of Neurosciences, University of Verona, Verona, Italy aut Moretto Giuseppe Department of Neurosciences, University of Verona, Verona, Italy aut Giometto Bruno Neurology Unit, Cà Foncello Hospital, Treviso, Italy aut Macerollo Antonella Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy aut Defazio Giovanni Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 627-633 0340-5354 258:4<627 2011 258 415 https://doi.org/10.1007/s00415-010-5812-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5812-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zambito Marsala Sandro Neurology Unit, San Martino Hospital, Belluno, Italy aut NATIONALLICENCE 700 1- Tinazzi Michele Department of Neurosciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Vitaliani Roberta Neurology Unit, Cà Foncello Hospital, Treviso, Italy aut NATIONALLICENCE 700 1- Recchia Serena Department of Neurosciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Fabris Federico Neurology Unit, San Martino Hospital, Belluno, Italy aut NATIONALLICENCE 700 1- Marchini Corrado Neurology Unit, San Martino Hospital, Belluno, Italy aut NATIONALLICENCE 700 1- Fiaschi Antonio Department of Neurosciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Moretto Giuseppe Department of Neurosciences, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Giometto Bruno Neurology Unit, Cà Foncello Hospital, Treviso, Italy aut NATIONALLICENCE 700 1- Macerollo Antonella Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Defazio Giovanni Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 627-633 0340-5354 258:4<627 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer